PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
Protein Summary
Acts as a coactivator during transcriptional activation of nuclear genes related to mitochondrial biogenesis and cell growth. Involved in the transcription coactivation of CREB and NRF1 target genes. The protein encoded by this gene is similar to PPAR-gamma coactivator 1 (PPARGC1/PGC-1), a protein that can activate mitochondrial biogenesis in part through a direct interaction with nuclear respiratory factor 1 (NRF1). This protein has been shown to interact with NRF1. It is thought to be a functional relative of PPAR-gamma coactivator 1 that activates mitochondrial biogenesis through NRF1 in response to proliferative signals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
- ENST00000278070
- ENSP00000278070
- ENSG00000148840
- KIAA0595
- PRC
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 1 | ||
transcription factor binding site profile | 0.96 | ||
disease perturbation | 0.74 | ||
cell type or tissue | 0.68 | ||
molecular function | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 510.28 (req: < 5)
Gene RIFs: 16 (req: <= 3)
Antibodies: 118 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 510.28 (req: >= 5)
Gene RIFs: 16 (req: > 3)
Antibodies: 118 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (69)
CA10
Family: Enzyme
Novelty: 0.01053152
p_int: 0.999998575
p_ni: 4.16e-7
p_wrong: 0.000001009
Score: 0.228
Data Source: BioPlex,STRINGDB
PIP4K2A
Family: Kinase
Novelty: 0.01130885
p_int: 0.999744185
p_ni: 6.39e-7
p_wrong: 0.000255175
Score: 0.181
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (5)
Reactome (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Mitochondrial biogenesis | ||||
Reactome | Organelle biogenesis and maintenance | ||||
Reactome | Transcriptional activation of mitochondrial biogenesis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Mitochondrial biogenesis | ||||
Organelle biogenesis and maintenance | ||||
Transcriptional activation of mitochondrial biogenesis | ||||
Viral Interactions (0)
Gene Ontology Terms (8)
Functions (3)
Components (2)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Disease Associations (null)
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 3 | 6 | 6.6 | 92.7 | ||||
cognitive function measurement | 2 | 3 | 3 | 90.7 | |||||
intelligence | 4 | 8 | 7 | 6.2 | 90.1 | ||||
mean reticulocyte volume | 1 | 2 | 2 | 81.6 | |||||
mean corpuscular volume | 1 | 1 | 1 | 77.9 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 6 | 6.6 | 92.7 | ||||
cognitive function measurement | 3 | 90.7 | |||||
intelligence | 7 | 6.2 | 90.1 | ||||
mean reticulocyte volume | 2 | 81.6 | |||||
mean corpuscular volume | 1 | 77.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 450696 | ||||||
Macaque | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | 712721 | ||||||
Mouse | MGI:2385096 | 226169 | ||||||
Rat | RGD:1309688 | 294007 | ||||||
Dog | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | VGNC:44928 | 477805 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | |||||
Macaque | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | peroxisome proliferator-activated receptor gamma, coactivator-related 1 | |||||
Publication Statistics
PubMed Score 510.28
PubMed score by year
PubTator Score 32.63
PubTator score by year
Related Publications
Text Mined References (25)
GeneRif Annotations (16)
Items per page:
0 of 0
PMID | Year | Title |
|---|