PPP4R4
Serine/threonine-protein phosphatase 4 regulatory subunit 4
Protein Summary
Putative regulatory subunit of serine/threonine-protein phosphatase 4. The protein encoded by this gene is a HEAT-like repeat-containing protein. The HEAT repeat is a tandemly repeated, 37-47 amino acid long module occurring in a number of cytoplasmic proteins. Arrays of HEAT repeats form a rod-like helical structure and appear to function as protein-protein interaction surfaces. The repeat-containing region of this protein has some similarity to the constant regulatory domain of the protein phosphatase 2A PR65/A subunit. The encoded protein binds protein serine/threonine phosphatase 4c in the cytoplasm. [provided by RefSeq, Jan 2017]
- ENST00000304338
- ENSP00000305924
- ENSG00000119698
- ENST00000328839
- ENSP00000330831
- ENST00000614957
- ENSP00000482849
- ENSG00000278326
- ENST00000619905
- ENSP00000480902
- KIAA1622
- PP4R4
- PP4R4
- CFAP14
- KIAA1622
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.74 | ||
virus perturbation | 0.72 | ||
microRNA | 0.71 | ||
small molecule perturbation | 0.51 | ||
cell line | 0.49 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.49 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 40 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.49 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 40 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0