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Tbio
PPP4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Protein Summary
Description
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554684
  • ENSP00000450864
  • ENSG00000100796
  • ENST00000554943
  • ENSP00000450883
  • ENST00000555462
  • ENSP00000450891

Symbol
  • KIAA2010
  • PP4R3A
  • SMEK1
  • smk1
  • FLFL1
  • PP4R3
  • SMEK1
  • smk-1
  • PP4R3A
  • MSTP033
  • KIAA2010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.01   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
PPP4R2
Tbio
Family:  Enzyme
Novelty:  0.15136638
p_int:  1
Score:  0.991
Data Source:  BioPlex,STRINGDB
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
p_int:  0.999988258
p_ni:  0.000011724
p_wrong:  1.8e-8
Score:  0.965
Data Source:  BioPlex,STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
p_int:  0.999810571
p_ni:  0.000189429
Score:  0.328
Data Source:  BioPlex,STRINGDB
LRRTM4
Tbio
Novelty:  0.07741851
p_int:  0.999249034
p_ni:  0.000750966
Data Source:  BioPlex
USP10
Tchem
Family:  Enzyme
Novelty:  0.05830541
p_int:  0.99831525
p_ni:  0.001684747
p_wrong:  3e-9
Score:  0.421
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.998044892
p_ni:  0.001955104
p_wrong:  4e-9
Data Source:  BioPlex
TSSC4
Tdark
Novelty:  0.17064786
p_int:  0.997629233
p_ni:  0.002370754
p_wrong:  1.3e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
CRAMP1
Tdark
Novelty:  0.26519971
p_int:  0.997379114
p_ni:  0.002620876
p_wrong:  1.1e-8
Score:  0.571
Data Source:  BioPlex,STRINGDB
PPP4C
Tbio
Family:  Enzyme
Novelty:  0.00705824
p_int:  0.997069252
p_ni:  0.002930748
Score:  0.997
Data Source:  BioPlex,STRINGDB
MARCKSL1
Tbio
Novelty:  0.01290798
p_int:  0.996862954
p_ni:  0.003137046
Score:  0.293
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
67.4
mean corpuscular volume
1
1
1
57.8
3
1
2
1
53.7
white matter hyperintensity measurement
3
2
3
52.4
3
1
0
1.1
46.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
67.4
mean corpuscular volume
1
57.8
2
1
53.7
white matter hyperintensity measurement
3
52.4
0
1.1
46.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 27.01
PubMed score by year
PubTator Score 4.81
PubTator score by year
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Related Publications
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PMID
Year
Title