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Tbio
PPP4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

Protein Summary
Description
Regulatory subunit of serine/threonine-protein phosphatase 4. May regulate the activity of PPP4C at centrosomal microtubule organizing centers. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on 'Ser-140' (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000554684
  • ENSP00000450864
  • ENSG00000100796
  • ENST00000554943
  • ENSP00000450883
  • ENST00000555462
  • ENSP00000450891

Symbol
  • KIAA2010
  • PP4R3A
  • SMEK1
  • smk1
  • FLFL1
  • PP4R3
  • SMEK1
  • smk-1
  • PP4R3A
  • MSTP033
  • KIAA2010
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.14   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.14   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0