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Tbio
PPP4R1
Serine/threonine-protein phosphatase 4 regulatory subunit 1

Protein Summary
Description
Regulatory subunit of serine/threonine-protein phosphatase 4. May play a role in regulation of cell division in renal glomeruli. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. This gene encodes one of several alternate regulatory subunits of serine/threonine protein phosphatase 4 (PP4). The protein features multiple HEAT repeats. This protein forms a complex with PP4RC. This complex may have a distinct role from other PP4 complexes, including regulation of HDAC3 (Zhang et al., PMID: 15805470). There is also a transcribed pseudogene on chromosome 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000400555
  • ENSP00000383401
  • ENSG00000154845
  • ENST00000400556
  • ENSP00000383402

Symbol
  • MEG1
  • PP4R1
  • MEG1
  • PP4R1
  • PP4(Rmeg)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
disease perturbation
0.83
histone modification site profile
0.73
cell line
0.62
virus perturbation
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.9   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (96)
CCDC6
Tbio
Novelty:  0.00702098
p_int:  1
Score:  0.79
Data Source:  BioPlex,STRINGDB
PMPCB
Tbio
Family:  Enzyme
Novelty:  0.0244013
p_int:  0.999997116
p_ni:  0.000002883
Score:  0.26
Data Source:  BioPlex,STRINGDB
RALBP1
Tbio
Novelty:  0.01525176
p_int:  0.99999452
p_ni:  0.00000548
Score:  0.377
Data Source:  BioPlex,STRINGDB
MAP7
Tbio
Novelty:  0.01976296
p_int:  0.999991089
p_ni:  0.000008911
Score:  0.72
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999907275
p_ni:  0.000092694
p_wrong:  3.1e-8
Score:  0.953
Data Source:  BioPlex,STRINGDB
KLHL11
Tbio
Novelty:  0.1537041
p_int:  0.99987613
p_ni:  0.000121019
p_wrong:  0.000002851
Data Source:  BioPlex
C1S
Tchem
Novelty:  0.00043003
p_int:  0.999763697
p_ni:  0.000236294
p_wrong:  1e-8
Score:  0.847
Data Source:  BioPlex,STRINGDB
KIF1B
Tbio
Novelty:  0.00984332
p_int:  0.967643931
p_ni:  0.029173334
p_wrong:  0.003182735
Score:  0.189
Data Source:  BioPlex,STRINGDB
PPP4C
Tbio
Family:  Enzyme
Novelty:  0.00705824
Score:  0.993
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.94
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
2
3
95.1
mathematical ability
3
3
3
76.4
platelet count
1
1
1
65.3
serum albumin measurement
1
1
1
36.5
cognitive function measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
95.1
mathematical ability
3
76.4
platelet count
1
65.3
serum albumin measurement
1
36.5
cognitive function measurement
1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 4 regulatory subunit 1
VGNC:5195
455291
Mouse
MGI:1917601
70351
Rat
RGD:619798
140943
Dog
protein phosphatase 4 regulatory subunit 1
VGNC:53875
480207
Horse
protein phosphatase 4 regulatory subunit 1
VGNC:21789
100055125
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 4 regulatory subunit 1
Mouse
Rat
Dog
protein phosphatase 4 regulatory subunit 1
Horse
protein phosphatase 4 regulatory subunit 1
Publication Statistics
PubMed Score 10.90
PubMed score by year
PubTator Score 6.29
PubTator score by year
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Related Publications
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PMID
Year
Title