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Tbio
PPP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

Protein Summary
Description
Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, DNA repair, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA double strand break repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase (By similarity). In response to DNA damage, catalyzes RPA2 dephosphorylation, an essential step for DNA repair since it allows the efficient RPA2-mediated recruitment of RAD51 to chromatin.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279387
  • ENSP00000279387
  • ENSG00000149923
  • ENST00000561610
  • ENSP00000455995

Symbol
  • PPP4
  • PPX
  • PP4
  • PPX
  • PP-X
  • PP4C
  • PPH3
  • PPP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.85
disease perturbation
0.83
molecular function
0.81
tissue
0.73
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.97   (req: < 5)
Gene RIFs: 28   (req: <= 3)
Antibodies: 380   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 217.97   (req: >= 5)
Gene RIFs: 28   (req: > 3)
Antibodies: 380   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (173)
PPP4R2
Tbio
Family:  Enzyme
Novelty:  0.15136638
p_int:  0.999996731
p_ni:  0.000003269
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
CCDC6
Tbio
Novelty:  0.00702098
p_int:  0.998101655
p_ni:  0.001898345
Score:  0.904
Data Source:  BioPlex,STRINGDB
PPP2R2D
Tbio
Family:  Enzyme
Novelty:  0.0658328
p_int:  0.998031976
p_ni:  0.001968024
Score:  0.798
Data Source:  BioPlex,STRINGDB
PPP4R3A
Tbio
Family:  Enzyme
Novelty:  0.04234592
p_int:  0.997069252
p_ni:  0.002930748
Score:  0.997
Data Source:  BioPlex,STRINGDB
PPP4R4
Tdark
Family:  Enzyme
Novelty:  0.72784619
p_int:  0.994327088
p_ni:  0.005672912
Score:  0.954
Data Source:  BioPlex,STRINGDB
LCMT1
Tbio
Family:  Enzyme
Novelty:  0.03504409
p_int:  0.873735571
p_ni:  0.126264429
Score:  0.916
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.85004184
p_ni:  0.14995816
Score:  0.923
Data Source:  BioPlex,STRINGDB
PPP4R3B
Tbio
Family:  Enzyme
Novelty:  0.0185504
Score:  0.999
Data Source:  STRINGDB
PPP4R1
Tbio
Family:  Enzyme
Novelty:  0.10822249
Score:  0.993
Data Source:  STRINGDB
RPA2
Tbio
Novelty:  0.00879115
Score:  0.976
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
DNA Double-Strand Break Repair (R-HSA-5693532)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Reactome
Homology Directed Repair
Reactome
Processing of DNA double-strand break ends
Name
Explore in Pharos
Explore in Source
DNA Double-Strand Break Repair
DNA Repair
HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA)
Homology Directed Repair
Processing of DNA double-strand break ends
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
4
4
94.4
appendicular lean mass
2
4
4
94.1
multiple sclerosis
2
2
0
1.1
87.9
mean corpuscular volume
3
2
3
85.4
schizophrenia
5
2
2
1.1
82.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
4
94.4
appendicular lean mass
4
94.1
multiple sclerosis
0
1.1
87.9
mean corpuscular volume
3
85.4
schizophrenia
2
1.1
82.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 4 catalytic subunit
VGNC:5891
739184
Macaque
protein phosphatase 4 catalytic subunit
708510
Mouse
MGI:1891763
56420
Rat
RGD:621225
171366
Dog
protein phosphatase 4 catalytic subunit
VGNC:44921
489947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 4 catalytic subunit
Macaque
protein phosphatase 4 catalytic subunit
Mouse
Rat
Dog
protein phosphatase 4 catalytic subunit
Publication Statistics
PubMed Score 217.97
PubMed score by year
PubTator Score 432.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title