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Tbio
PPP3R2
Calcineurin subunit B type 2

Protein Summary
Description
Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374806
  • ENSP00000363939
  • ENSG00000188386

Symbol
  • CBLP
  • PPP3RL
  • PPP3RL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.61
disease perturbation
0.56
cell type or tissue
0.55
microRNA
0.54
gene perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.03   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 162   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.03   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.999999919
p_ni:  4.9e-8
p_wrong:  3.1e-8
Score:  0.368
Data Source:  BioPlex,STRINGDB
SIK3
Tchem
Family:  Kinase
Novelty:  0.02936655
p_int:  0.999996244
p_ni:  0.000003752
p_wrong:  3e-9
Data Source:  BioPlex
PPP3CC
Tbio
Family:  Enzyme
Novelty:  0.02633046
p_int:  0.999990812
p_ni:  0.000007885
p_wrong:  0.000001304
Score:  0.971
Data Source:  BioPlex,STRINGDB
ANKRD33B
Tdark
Novelty:  3.05956917
p_int:  0.999979416
p_wrong:  0.000020584
Data Source:  BioPlex
PPP3CB
Tbio
Family:  Enzyme
Novelty:  0.02156713
p_int:  0.999958137
p_ni:  0.000041864
Score:  0.97
Data Source:  BioPlex,STRINGDB
PPP3CA
Tchem
Family:  Enzyme
Novelty:  0.00234189
p_int:  0.999297527
p_ni:  0.000702473
Score:  0.967
Data Source:  BioPlex,STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
p_int:  0.994882937
p_ni:  0.004575482
p_wrong:  0.000541581
Data Source:  BioPlex
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.991236282
p_ni:  0.008763718
Score:  0.186
Data Source:  BioPlex,STRINGDB
MOSPD2
Tbio
Novelty:  0.14602473
p_int:  0.913156326
p_ni:  0.086830968
p_wrong:  0.000012707
Data Source:  BioPlex
HERC3
Tbio
Family:  Enzyme
Novelty:  0.05231675
p_int:  0.75281044
p_ni:  0.24718956
Data Source:  BioPlex
Nearest Tclin Targets (6)
Explore Nearest Tclin Targets
1 – 3 of 3
Pathways (53)
Find Similar Targets
Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Axon guidance
KEGG
Oxytocin signaling pathway
KEGG
T cell receptor signaling pathway
KEGG
B cell receptor signaling pathway
KEGG
Kaposi sarcoma-associated herpesvirus infection
Name
Explore in Pharos
Explore in Source
Axon guidance
Oxytocin signaling pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
Kaposi sarcoma-associated herpesvirus infection
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
40.7
self reported educational attainment
1
1
1
33.1
mathematical ability
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
40.7
self reported educational attainment
1
33.1
mathematical ability
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:107171
19059
Rat
RGD:69232
29749
S.cerevisiae
S000001673
853644
Publication Statistics
PubMed Score 82.03
PubMed score by year
PubTator Score 12.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title