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Tchem
PPP3CA
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Protein Summary
Description
Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:262480 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323055
  • ENSP00000320580
  • ENSG00000138814
  • ENST00000394853
  • ENSP00000378322
  • ENST00000394854
  • ENSP00000378323
  • ENST00000512215
  • ENSP00000422781

Symbol
  • CALNA
  • CNA
  • CALN
  • CCN1
  • CNA1
  • CALNA
  • IECEE
  • PPP2B
  • ACCIID
  • CALNA1
  • IECEE1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
kinase perturbation
1
transcription factor perturbation
0.96
transcription factor binding site profile
0.89
hub protein
0.88


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.35   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 531   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.35   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 531   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (18)
tacrolimus
Rendered image for tacrolimus
CHEMBL275103
Rendered image for CHEMBL275103
CHEMBL65863
Rendered image for CHEMBL65863
CHEMBL305081
Rendered image for CHEMBL305081
CHEMBL266705
Rendered image for CHEMBL266705
CHEMBL268110
Rendered image for CHEMBL268110
CHEMBL431368
Rendered image for CHEMBL431368
CHEMBL264568
Rendered image for CHEMBL264568
CHEMBL407332
Rendered image for CHEMBL407332
Protein-Protein Interactions (272)
RCAN1
Tbio
Novelty:  0.0030009
p_int:  1
Score:  0.954
Data Source:  BioPlex,STRINGDB
RCAN3
Tbio
Novelty:  0.12819457
p_int:  1
Score:  0.873
Data Source:  BioPlex,STRINGDB
FAM122A
Tbio
Novelty:  0.3107759
p_int:  1
Score:  0.739
Data Source:  BioPlex,STRINGDB
NFATC4
Tbio
Family:  TF
Novelty:  0.00788306
p_int:  0.999999356
p_ni:  6.39e-7
p_wrong:  5e-9
Score:  0.852
Data Source:  BioPlex,STRINGDB
SIK3
Tchem
Family:  Kinase
Novelty:  0.02936655
p_int:  0.999989022
p_ni:  0.000010978
Score:  0.353
Data Source:  BioPlex,STRINGDB
PPP3R1
Tbio
Novelty:  0.00263264
p_int:  0.999953996
p_ni:  0.000045949
p_wrong:  5.5e-8
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.999505609
p_ni:  0.000494391
Data Source:  BioPlex
PPP3R2
Tbio
Novelty:  0.01121867
p_int:  0.999297527
p_ni:  0.000702473
Score:  0.967
Data Source:  BioPlex,STRINGDB
TMEM200A
Tdark
Novelty:  0.25580793
p_int:  0.997547643
p_ni:  0.002452357
Score:  0.524
Data Source:  BioPlex,STRINGDB
RCAN2
Tbio
Novelty:  0.00174006
p_int:  0.997092214
p_ni:  0.002907786
Score:  0.832
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets (8)
Explore Nearest Tclin Targets
Pathways (77)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Beta-catenin independent WNT signaling
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) induces NFAT activation
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Beta-catenin independent WNT signaling
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) induces NFAT activation
CLEC7A (Dectin-1) signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (54)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
52.7
testosterone measurement
1
1
1
27.3
1
1
1
21.5
1
1
0
1.2
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
52.7
testosterone measurement
1
27.3
1
21.5
0
1.2
17.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit alpha
VGNC:7727
461403
Macaque
protein phosphatase 3 catalytic subunit alpha
709773
Mouse
MGI:107164
19055
Rat
RGD:3382
24674
Dog
protein phosphatase 3 catalytic subunit alpha
VGNC:44918
403486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 3 catalytic subunit alpha
Macaque
protein phosphatase 3 catalytic subunit alpha
Mouse
Rat
Dog
protein phosphatase 3 catalytic subunit alpha
Publication Statistics
PubMed Score 455.35
PubMed score by year
PubTator Score 31.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title