Tchem PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform

Protein Summary

Description

Calcium-dependent, calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020, PubMed:18838687, PubMed:19154138, PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738, PubMed:17502104, PubMed:23468591, PubMed:27974827, PubMed:22343722). In response to increased Ca(2+) levels, dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization, dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels, regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).

Uniprot Accession IDs

• Q08209
• A1A441
• A8K3B7
• A8W6Z7
• A8W6Z8
• B5BUA2
• Q8TAW9

Gene Name

• PPP3CA

Ensembl ID

• ENST00000323055
• ENSP00000320580
• ENSG00000138814
• ENST00000394853
• ENSP00000378322
• ENST00000394854
• ENSP00000378323
• ENST00000512215
• ENSP00000422781

Symbol

• CALNA
• CNA
• CALN
• CCN1
• CNA1
• CALNA
• IECEE
• PPP2B
• ACCIID
• CALNA1
• IECEE1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
kinase perturbation	1
transcription factor perturbation	0.96
transcription factor binding site profile	0.89
hub protein	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.12   (req: < 5)

Gene RIFs: 77   (req: <= 3)

Antibodies: 531   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 722.12   (req: >= 5)

Gene RIFs: 77   (req: > 3)

Antibodies: 531   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 18

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2