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Tbio
PPP2R5E
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit epsilon isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000337537
  • ENSP00000337641
  • ENSG00000154001
  • ENST00000422769
  • ENSP00000404632
  • ENST00000555899
  • ENSP00000452396

Symbol
  • B56E
  • B56epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
disease perturbation
0.98
kinase perturbation
0.97
histone modification site profile
0.9
transcription factor perturbation
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.87   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.87   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (326)
WNT3A
Tchem
Novelty:  0.00119275
p_int:  0.999997337
p_ni:  0.000002663
Score:  0.913
Data Source:  BioPlex,STRINGDB
FAM43A
Tdark
Novelty:  1.17401589
p_int:  0.999996459
p_ni:  0.000003541
Score:  0.185
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999995711
p_ni:  0.000004288
Score:  0.998
Data Source:  BioPlex,STRINGDB
C1orf21
Tdark
Novelty:  0.33595495
p_int:  0.999995456
p_ni:  0.000004542
p_wrong:  2e-9
Data Source:  BioPlex
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999990776
p_ni:  0.000009224
Score:  0.997
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999983375
p_ni:  0.000016625
Score:  0.172
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.999937696
p_ni:  0.000062304
Data Source:  BioPlex
GRIN2A
Tclin
Family:  IC
Novelty:  0.00060035
p_int:  0.999829049
p_ni:  0.000170951
Data Source:  BioPlex
ZFPL1
Tbio
Novelty:  0.1829181
p_int:  0.998246988
p_ni:  0.001753012
Data Source:  BioPlex
DCAF11
Tbio
Novelty:  0.08318661
p_int:  0.997570421
p_ni:  0.002429579
Data Source:  BioPlex
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
CACNA1D
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA1S
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
RYR2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (83)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
17.8
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'epsilon
VGNC:10312
452962
Macaque
protein phosphatase 2 regulatory subunit B'epsilon
708583
Mouse
MGI:1349473
26932
Rat
RGD:1305657
299147
Dog
protein phosphatase 2 regulatory subunit B'epsilon
VGNC:44917
480349
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'epsilon
Macaque
protein phosphatase 2 regulatory subunit B'epsilon
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B'epsilon
Publication Statistics
PubMed Score 15.87
PubMed score by year
PubTator Score 6.05
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title