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Tchem
PPP2R5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261461
  • ENSP00000261461
  • ENSG00000066027
  • ENST00000537030
  • ENSP00000442866

Symbol
  • B56A
  • PR61A
  • B56alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.99
transcription factor binding site profile
0.96
virus perturbation
0.94
transcription factor
0.82
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.4   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.4   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (315)
WNT3A
Tchem
Novelty:  0.00119275
p_int:  0.999999987
p_ni:  1.1e-8
p_wrong:  2e-9
Score:  0.923
Data Source:  BioPlex,STRINGDB
C1orf21
Tdark
Novelty:  0.33595495
p_int:  0.999999954
p_ni:  4.6e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.99999987
p_ni:  1.3e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
PPP2CB
Tbio
Family:  Enzyme
Novelty:  0.0483178
p_int:  0.999997093
p_ni:  0.000002907
Score:  0.99
Data Source:  BioPlex,STRINGDB
PRR14
Tbio
Novelty:  0.22401806
p_int:  0.999992257
p_ni:  0.000007742
p_wrong:  1e-9
Score:  0.747
Data Source:  BioPlex,STRINGDB
FAM43A
Tdark
Novelty:  1.17401589
p_int:  0.999910867
p_ni:  4.91e-7
p_wrong:  0.000088642
Score:  0.209
Data Source:  BioPlex,STRINGDB
MOS
Tbio
Family:  Kinase
Novelty:  0.05699356
p_int:  0.870393202
p_ni:  0.000089645
p_wrong:  0.129517154
Score:  0.426
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.998
Data Source:  STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
Score:  0.998
Data Source:  STRINGDB
BUB1B
Tbio
Family:  Kinase
Novelty:  0.00239073
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
CACNA1D
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
RYR2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA1S
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (76)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 56
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Reactome
Adaptive Immune System
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Adaptive Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
3
4
5
95.3
basophil percentage of leukocytes
1
2
2
79.5
monocyte count
1
1
1
78.9
BMI-adjusted waist circumference
1
2
2
60.8
neutrophil percentage of leukocytes
1
1
1
54.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
5
95.3
basophil percentage of leukocytes
2
79.5
monocyte count
1
78.9
BMI-adjusted waist circumference
2
60.8
neutrophil percentage of leukocytes
1
54.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'alpha
VGNC:10426
457716
Macaque
protein phosphatase 2 regulatory subunit B'alpha
716313
Mouse
MGI:2388479
226849
Rat
RGD:1308022
312754
Dog
protein phosphatase 2 regulatory subunit B'alpha
VGNC:44913
490280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B'alpha
Macaque
protein phosphatase 2 regulatory subunit B'alpha
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B'alpha
Publication Statistics
PubMed Score 30.40
PubMed score by year
PubTator Score 10.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title