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Tbio
PPP2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha su ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264977
  • ENSP00000264977
  • ENSG00000073711
  • ENST00000334546
  • ENSP00000334748
  • ENST00000490467
  • ENSP00000419344

Symbol
  • PPP2R3
  • PR72
  • PR130
  • PPP2R3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.84
transcription factor
0.79
disease perturbation
0.68
microRNA
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.19   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 36.19   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
LPP
Tbio
Novelty:  0.00624048
p_int:  0.999999998
p_ni:  2e-9
Score:  0.29
Data Source:  BioPlex,STRINGDB
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.999999556
p_ni:  4.44e-7
p_wrong:  1e-9
Score:  0.179
Data Source:  BioPlex,STRINGDB
ZNF785
Tdark
Family:  TF
Novelty:  0.42629766
p_int:  0.999991484
p_ni:  0.000008511
p_wrong:  5e-9
Data Source:  BioPlex
SFRP4
Tbio
Novelty:  0.00174428
p_int:  0.999987156
p_ni:  8.27e-7
p_wrong:  0.000012017
Score:  0.211
Data Source:  BioPlex,STRINGDB
CDK17
Tchem
Family:  Kinase
Novelty:  0.25046297
p_int:  0.999847649
p_ni:  0.000113662
p_wrong:  0.000038688
Score:  0.312
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.999739017
p_ni:  0.000260983
Score:  0.962
Data Source:  BioPlex,STRINGDB
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999617853
p_ni:  0.000063935
p_wrong:  0.000318212
Score:  0.171
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.999534543
p_ni:  0.000465457
Score:  0.862
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tchem
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999305445
p_ni:  0.00007276
p_wrong:  0.000621795
Data Source:  BioPlex
GTSE1
Tbio
Family:  Enzyme
Novelty:  0.0460569
p_int:  0.998529391
p_ni:  0.001470503
p_wrong:  1.07e-7
Data Source:  BioPlex
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
1 – 5 of 7
CACNA1C
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
CACNA1D
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  2
RYR2
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
CACNA2D1
Tclin
Family:  Ion Channel
KEGG Distance:  1
Common Pathways:  1
Pathways (15)
Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Dopaminergic synapse
KEGG
mRNA surveillance pathway
KEGG
AMPK signaling pathway
KEGG
Adrenergic signaling in cardiomyocytes
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Dopaminergic synapse
mRNA surveillance pathway
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (66)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
22
7
22
2.2
98.1
fibrinogen measurement
4
4
4
97.7
high density lipoprotein cholesterol measurement
21
7
21
94.8
very low density lipoprotein cholesterol measurement
43
7
43
84.9
testosterone measurement
2
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
22
2.2
98.1
fibrinogen measurement
4
97.7
high density lipoprotein cholesterol measurement
21
94.8
very low density lipoprotein cholesterol measurement
43
84.9
testosterone measurement
2
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B''alpha
VGNC:10493
460715
Macaque
protein phosphatase 2 regulatory subunit B''alpha
717078
Mouse
MGI:2442104
235542
Rat
RGD:1306958
363122
Dog
protein phosphatase 2 regulatory subunit B''alpha
VGNC:44911
485672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit B''alpha
Macaque
protein phosphatase 2 regulatory subunit B''alpha
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit B''alpha
Publication Statistics
PubMed Score 36.19
PubMed score by year
PubTator Score 19.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title