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Tbio
PPP2R2C
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Protein Summary
Description
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335585
  • ENSP00000335083
  • ENSG00000074211
  • ENST00000382599
  • ENSP00000372042
  • ENST00000506140
  • ENSP00000423649
  • ENST00000507294
  • ENSP00000425247
  • ENST00000515571
  • ENSP00000422374

Symbol
  • PR52
  • PR55G
  • IMYPNO
  • IMYPNO1
  • B55gamma
  • B55-GAMMA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.96
trait
0.75
protein domain
0.73
phenotype
0.68
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.58   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (178)
SKA3
Tbio
Novelty:  0.05435653
p_int:  0.999999697
p_ni:  2.98e-7
p_wrong:  5e-9
Score:  0.252
Data Source:  BioPlex,STRINGDB
CDCA4
Tbio
Novelty:  0.04549061
p_int:  0.999999536
p_ni:  3.71e-7
p_wrong:  9.3e-8
Score:  0.707
Data Source:  BioPlex,STRINGDB
SERTAD4
Tdark
Novelty:  0.70786986
p_int:  0.999998485
p_ni:  0.000001044
p_wrong:  4.71e-7
Score:  0.747
Data Source:  BioPlex,STRINGDB
FAM122B
Tdark
Novelty:  1.90668674
p_int:  0.999994331
p_ni:  0.000005668
p_wrong:  1e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
PPP2R2B
Tbio
Family:  Enzyme
Novelty:  0.01200339
p_int:  0.999985745
p_ni:  0.000014255
p_wrong:  1e-9
Score:  0.871
Data Source:  BioPlex,STRINGDB
SIK2
Tchem
Family:  Kinase
Novelty:  0.01957886
p_int:  0.999963282
p_ni:  0.000036716
p_wrong:  2e-9
Score:  0.656
Data Source:  BioPlex,STRINGDB
ZNF746
Tbio
Family:  TF
Novelty:  0.10426864
p_int:  0.999937447
p_ni:  0.000062553
Score:  0.242
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.999931796
p_ni:  0.000068203
Score:  0.992
Data Source:  BioPlex,STRINGDB
IER5
Tbio
Novelty:  0.06965213
p_int:  0.9999058
p_ni:  1.78e-7
p_wrong:  0.000094022
Score:  0.522
Data Source:  BioPlex,STRINGDB
MTCL1
Tbio
Novelty:  0.18671975
p_int:  0.999768579
p_ni:  0.000231421
Score:  0.183
Data Source:  BioPlex,STRINGDB
Pathways (19)
Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
PI3K-Akt signaling pathway
KEGG
Dopaminergic synapse
KEGG
Tight junction
KEGG
mRNA surveillance pathway
KEGG
AMPK signaling pathway
Name
Explore in Pharos
Explore in Source
PI3K-Akt signaling pathway
Dopaminergic synapse
Tight junction
mRNA surveillance pathway
AMPK signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
16
7
5
1.1
99.6
blood protein measurement
4
3
4
94
Drugs used in diabetes use measurement
3
2
3
75.7
hemoglobin A1 measurement
1
1
1
52.5
HbA1c measurement
1
3
3
52.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
type 2 diabetes mellitus
5
1.1
99.6
blood protein measurement
4
94
Drugs used in diabetes use measurement
3
75.7
hemoglobin A1 measurement
1
52.5
HbA1c measurement
3
52.4
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit Bgamma
VGNC:48887
461101
Macaque
protein phosphatase 2 regulatory subunit Bgamma
711023
Mouse
MGI:2442660
269643
Rat
RGD:620920
117256
Dog
protein phosphatase 2 regulatory subunit Bgamma
VGNC:44909
610262
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 regulatory subunit Bgamma
Macaque
protein phosphatase 2 regulatory subunit Bgamma
Mouse
Rat
Dog
protein phosphatase 2 regulatory subunit Bgamma
Publication Statistics
PubMed Score 26.58
PubMed score by year
PubTator Score 8.71
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title