PPP2R1B
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform
Protein Summary
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2010]
- ENST00000311129
- ENSP00000311344
- ENSG00000137713
- ENST00000341980
- ENSP00000343317
- ENST00000393055
- ENSP00000376775
- ENST00000426998
- ENSP00000410671
- ENST00000527614
- ENSP00000437193
- PR65B
- PP2A-Abeta
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.91 | ||
disease perturbation | 0.87 | ||
hub protein | 0.85 | ||
kinase perturbation | 0.76 | ||
tissue sample | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.98 (req: < 5)
Gene RIFs: 18 (req: <= 3)
Antibodies: 259 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 30.98 (req: >= 5)
Gene RIFs: 18 (req: > 3)
Antibodies: 259 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0