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Tbio
PPP2R1A
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Protein Summary
Description
The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887). This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322088
  • ENSP00000324804
  • ENSG00000105568

Symbol
  • MRD36
  • PP2AA
  • PR65A
  • PP2AAALPHA
  • PP2A-Aalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
biological process
0.98
co-expressed gene
0.98
disease perturbation
0.96
interacting protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.46   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 359   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 106.46   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 359   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (703)
PPP2R5B
Tbio
Family:  Enzyme
Novelty:  0.08980945
p_int:  0.99999999
p_ni:  1e-8
Score:  0.997
Data Source:  BioPlex,STRINGDB
PPP2R5D
Tbio
Family:  Enzyme
Novelty:  0.03990599
p_int:  0.999999944
p_ni:  5.6e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
PPP2R5A
Tchem
Family:  Enzyme
Novelty:  0.03073487
p_int:  0.99999987
p_ni:  1.3e-7
Score:  0.998
Data Source:  BioPlex,STRINGDB
PPP2R3B
Tbio
Family:  Enzyme
Novelty:  0.02932064
p_int:  0.999999747
p_ni:  2.53e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
ANKLE2
Tbio
Novelty:  0.0995907
p_int:  0.999999538
p_ni:  4.45e-7
p_wrong:  1.7e-8
Score:  0.392
Data Source:  BioPlex,STRINGDB
PPP2R1B
Tbio
Family:  Enzyme
Novelty:  0.03936638
p_int:  0.999999503
p_ni:  4.97e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
p_int:  0.999997661
p_ni:  0.000002339
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
PPFIA3
Tbio
Novelty:  0.03837299
p_int:  0.999997639
p_ni:  0.00000236
Score:  0.483
Data Source:  BioPlex,STRINGDB
PPP2R3C
Tbio
Family:  Enzyme
Novelty:  0.02970644
p_int:  0.999995933
p_ni:  0.00000403
p_wrong:  3.7e-8
Score:  0.703
Data Source:  BioPlex,STRINGDB
PPP2R5E
Tbio
Family:  Enzyme
Novelty:  0.05974697
p_int:  0.999995711
p_ni:  0.000004288
Score:  0.998
Data Source:  BioPlex,STRINGDB
Pathways (165)
AMER1 mutants destabilize the destruction complex (R-HSA-4839748)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AMER1 mutants destabilize the destruction complex
Reactome
APC truncation mutants have impaired AXIN binding
Reactome
AURKA Activation by TPX2
Reactome
AXIN missense mutants destabilize the destruction complex
Reactome
AXIN mutants destabilize the destruction complex, activating WNT signaling
Name
Explore in Pharos
Explore in Source
AMER1 mutants destabilize the destruction complex
APC truncation mutants have impaired AXIN binding
AURKA Activation by TPX2
AXIN missense mutants destabilize the destruction complex
AXIN mutants destabilize the destruction complex, activating WNT signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (44)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 scaffold subunit Aalpha
VGNC:10196
468983
Macaque
protein phosphatase 2 scaffold subunit Aalpha
719929
Mouse
MGI:1926334
51792
Rat
RGD:620907
117281
Dog
protein phosphatase 2 scaffold subunit Aalpha
VGNC:44905
484335
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 2 scaffold subunit Aalpha
Macaque
protein phosphatase 2 scaffold subunit Aalpha
Mouse
Rat
Dog
protein phosphatase 2 scaffold subunit Aalpha
Publication Statistics
PubMed Score 106.46
PubMed score by year
PubTator Score 34.82
PubTator score by year
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Related Publications
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PMID
Year
Title