Tbio PPP1R9A Neurabin-1

Protein Summary

Description

Binds to actin filaments (F-actin) and shows cross-linking activity. Binds along the sides of the F-actin. May be involved in neurite formation. Inhibits protein phosphatase 1-alpha activity (By similarity). This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9ULJ8
• A1L494
• B2RWQ1
• E9PCA0
• E9PCK6
• E9PDX1
• F8W7J9
• O76059
• Q9NXT2

Gene Name

• PPP1R9A

Ensembl ID

• ENST00000289495
• ENSP00000289495
• ENSG00000158528
• ENST00000340694
• ENSP00000344524
• ENST00000424654
• ENSP00000411342
• ENST00000433360
• ENSP00000405514
• ENST00000433881
• ENSP00000398870
• ENST00000456331
• ENSP00000402893

Symbol

• KIAA1222
• NRB1
• NRBI
• Neurabin-I

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
trait	0.86
microRNA	0.81
transcription factor perturbation	0.8
transcription factor	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 137   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.57   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 137   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0