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Tbio
PPP1R3C
Protein phosphatase 1 regulatory subunit 3C

Protein Summary
Description
Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown. Dramatically increases basal and insulin-stimulated glycogen synthesis upon overexpression in a variety of cell types. This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000238994
  • ENSP00000238994
  • ENSG00000119938

Symbol
  • PPP1R5
  • PTG
  • PPP1R5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.99
small molecule perturbation
0.96
disease perturbation
0.83
virus perturbation
0.76
PubMedID
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.68   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 50.68   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (93)
STBD1
Tbio
Novelty:  0.08362185
p_int:  0.999999413
p_ni:  4.6e-8
p_wrong:  5.41e-7
Score:  0.885
Data Source:  BioPlex,STRINGDB
PPP1R3D
Tdark
Family:  Enzyme
Novelty:  0.53609018
p_int:  0.999995
p_ni:  3.11e-7
p_wrong:  0.000004689
Score:  0.973
Data Source:  BioPlex,STRINGDB
GYS1
Tchem
Family:  Enzyme
Novelty:  0.00721964
p_int:  0.997286599
p_ni:  0.002713401
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.995499278
p_ni:  0.004477008
p_wrong:  0.000023714
Data Source:  BioPlex
AASDHPPT
Tbio
Family:  Enzyme
Novelty:  0.00443438
p_int:  0.974005856
p_ni:  0.025994144
Score:  0.199
Data Source:  BioPlex,STRINGDB
GYS2
Tbio
Family:  Enzyme
Novelty:  0.01522741
p_int:  0.820755438
p_ni:  0.179141065
p_wrong:  0.000103497
Score:  0.992
Data Source:  BioPlex,Reactome,STRINGDB
GYG1
Tbio
Family:  Enzyme
Novelty:  0.01446978
p_int:  0.819621027
p_ni:  0.180378973
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
TXNRD2
Tbio
Family:  Enzyme
Novelty:  0.002052
p_int:  0.790903936
p_ni:  0.19391234
p_wrong:  0.015183723
Score:  0.28
Data Source:  BioPlex,STRINGDB
GNG5
Tbio
Novelty:  0.1525101
p_int:  0.779984612
p_ni:  0.139330535
p_wrong:  0.080684853
Score:  0.175
Data Source:  BioPlex,STRINGDB
B3EWF7
Tbio
Novelty:  0.00846992
Score:  0.989
Data Source:  STRINGDB
Pathways (14)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Glycogen metabolism
Reactome
Glycogen storage diseases
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Glycogen metabolism
Glycogen storage diseases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
2
3
47.4
intelligence
2
2
1
5.5
38.8
self reported educational attainment
2
2
2
38.7
mitochondrial heteroplasmy measurement
1
1
1
7.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cognitive function measurement
3
47.4
intelligence
1
5.5
38.8
self reported educational attainment
2
38.7
mitochondrial heteroplasmy measurement
1
7.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3C
VGNC:12430
450596
Macaque
protein phosphatase 1 regulatory subunit 3C
697381
Mouse
MGI:1858229
53412
Rat
RGD:1309132
309513
Dog
protein phosphatase 1 regulatory subunit 3C
VGNC:44898
477766
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 3C
Macaque
protein phosphatase 1 regulatory subunit 3C
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 3C
Publication Statistics
PubMed Score 50.68
PubMed score by year
PubTator Score 27.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title