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Tdark
PPP1R35
Protein phosphatase 1 regulatory subunit 35

Protein Summary
Description
Inhibits PPP1CA phosphatase activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292330
  • ENSP00000292330
  • ENSG00000160813

Symbol
  • C7orf47
  • C7orf47
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.76
cell type or tissue
0.64
tissue sample
0.61
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 67   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 67   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
BAHD1
Tbio
Novelty:  0.1601376
Score:  0.78
Data Source:  STRINGDB
CAMTA2
Tbio
Family:  TF
Novelty:  0.06741618
Score:  0.774
Data Source:  STRINGDB
DCP2
Tbio
Family:  Enzyme
Novelty:  0.00661786
Score:  0.764
Data Source:  STRINGDB
ASNSD1
Tdark
Family:  Enzyme
Novelty:  0.54006324
Score:  0.743
Data Source:  STRINGDB
ASDURF
Tdark
Novelty:  0.54006324
Score:  0.743
Data Source:  STRINGDB
DRAP1
Tbio
Novelty:  0.05872031
Score:  0.723
Data Source:  STRINGDB
ECI1
Tbio
Family:  Enzyme
Novelty:  0.01936227
Score:  0.718
Data Source:  STRINGDB
DCP1A
Tbio
Novelty:  0.02038933
Score:  0.696
Data Source:  STRINGDB
C7orf61
Tdark
Novelty:  3.9028559
Score:  0.685
Data Source:  STRINGDB
CCDC174
Tdark
Novelty:  0.37189828
Score:  0.669
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
2
1
4
92.3
Alzheimer disease
3
2
0
6.7
91.4
family history of Alzheimer’s disease
2
2
0
7.5
89.4
hemoglobin measurement
2
2
2
82.1
educational attainment
1
3
3
82
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
92.3
Alzheimer disease
0
6.7
91.4
family history of Alzheimer’s disease
0
7.5
89.4
hemoglobin measurement
2
82.1
educational attainment
3
82
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 35
VGNC:4477
463599
Macaque
protein phosphatase 1 regulatory subunit 35
712067
Mouse
MGI:1922853
69871
Rat
RGD:6497600
100910581
Dog
protein phosphatase 1 regulatory subunit 35
VGNC:44893
479735
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 35
Macaque
protein phosphatase 1 regulatory subunit 35
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 35
Publication Statistics
PubMed Score 2.00
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
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PMID
Year
Title