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Tdark
PPP1R21
Protein phosphatase 1 regulatory subunit 21

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281394
  • ENSP00000281394
  • ENSG00000162869
  • ENST00000294952
  • ENSP00000294952
  • ENST00000449090
  • ENSP00000415696

Symbol
  • CCDC128
  • KLRAQ1
  • KLRAQ1
  • CCDC128
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.79
histone modification site profile
0.74
tissue sample
0.74
transcription factor perturbation
0.68
kinase perturbation
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.4   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 93   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.4   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 93   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (44)
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999999969
p_ni:  2.7e-8
p_wrong:  4e-9
Data Source:  BioPlex
IL6R
Tclin
Novelty:  0.00185005
p_int:  0.999999824
p_ni:  1.76e-7
p_wrong:  1e-9
Score:  0.163
Data Source:  BioPlex,STRINGDB
FBXL14
Tbio
Novelty:  0.21211079
p_int:  0.999993218
p_ni:  0.000006781
p_wrong:  1e-9
Data Source:  BioPlex
THBS2
Tbio
Novelty:  0.00310724
p_int:  0.997022826
p_ni:  0.00297715
p_wrong:  2.4e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
RNF181
Tbio
Family:  Enzyme
Novelty:  0.27482636
p_int:  0.996728364
p_ni:  0.003267711
p_wrong:  0.000003925
Data Source:  BioPlex
WDTC1
Tbio
Novelty:  0.02300849
p_int:  0.991055186
p_ni:  0.008939961
p_wrong:  0.000004852
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.988358681
p_ni:  0.011641319
Data Source:  BioPlex
BTBD9
Tbio
Novelty:  0.02793632
p_int:  0.986704446
p_ni:  0.013295554
Score:  0.183
Data Source:  BioPlex,STRINGDB
KLHL26
Tdark
Novelty:  1.53240393
p_int:  0.967198721
p_ni:  0.032801279
Score:  0.187
Data Source:  BioPlex,STRINGDB
KLHL24
Tbio
Novelty:  0.04032749
p_int:  0.933523284
p_ni:  0.066475797
p_wrong:  9.2e-7
Score:  0.17
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (1)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
79.8
sex hormone-binding globulin measurement
4
2
4
74.6
reticulocyte count
3
3
3
59.5
mean corpuscular hemoglobin concentration
2
2
2
55.8
reticulocyte measurement
2
2
2
54.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
79.8
sex hormone-binding globulin measurement
4
74.6
reticulocyte count
3
59.5
mean corpuscular hemoglobin concentration
2
55.8
reticulocyte measurement
2
54.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 21
VGNC:6394
740025
Macaque
protein phosphatase 1 regulatory subunit 21
715917
Mouse
MGI:1921075
73825
Rat
RGD:1565310
362697
Dog
protein phosphatase 1 regulatory subunit 21
VGNC:44889
474586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 21
Macaque
protein phosphatase 1 regulatory subunit 21
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 21
Publication Statistics
PubMed Score 3.40
PubMed score by year
PubTator Score 1.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title