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Tbio
PPP1R2
Protein phosphatase inhibitor 2

Protein Summary
Description
Inhibitor of protein-phosphatase 1. Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000618156
  • ENSP00000484580
  • ENSG00000184203

Symbol
  • IPP2
  • IPP2
  • IPP-2
  • PPP1R2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.94
kinase
0.84
transcription factor perturbation
0.84
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.45   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.45   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999941
p_ni:  5.9e-8
Score:  0.989
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999845
p_ni:  1.55e-7
Score:  0.985
Data Source:  BioPlex,STRINGDB
GSK3A
Tclin
Family:  Kinase
Novelty:  0.00925708
p_int:  0.999967538
p_ni:  0.000032462
Score:  0.516
Data Source:  BioPlex,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.99
Data Source:  STRINGDB
PPP1R11
Tbio
Family:  Enzyme
Novelty:  0.08166535
Score:  0.982
Data Source:  STRINGDB
PPP1R7
Tbio
Family:  Enzyme
Novelty:  0.02088568
Score:  0.97
Data Source:  STRINGDB
PDIA5
Tbio
Family:  Enzyme
Novelty:  0.06234465
Score:  0.885
Data Source:  STRINGDB
POLR2G
Tbio
Family:  Enzyme
Novelty:  0.01235379
Score:  0.822
Data Source:  STRINGDB
SLK
Tchem
Family:  Kinase
Novelty:  0.00310721
Score:  0.822
Data Source:  STRINGDB
PPP2CA
Tchem
Family:  Enzyme
Novelty:  0.00496839
Score:  0.805
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
1
1
21.5
lymphocyte count
2
1
2
12.3
reticulocyte count
2
1
2
12.1
reticulocyte measurement
2
1
2
11.3
lymphocyte percentage of leukocytes
1
1
1
7.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
1
21.5
lymphocyte count
2
12.3
reticulocyte count
2
12.1
reticulocyte measurement
2
11.3
lymphocyte percentage of leukocytes
1
7.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 2
708936
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 2
Publication Statistics
PubMed Score 34.45
PubMed score by year
PubTator Score 57.84
PubTator score by year
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Related Publications
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PMID
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