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Tbio
PPP1R1A
Protein phosphatase 1 regulatory subunit 1A

Protein Summary
Description
Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000257905
  • ENSP00000257905
  • ENSG00000135447

Symbol
  • IPP1
  • I1
  • IPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.88
phosphatase
0.81
gene perturbation
0.76
co-expressed gene
0.72
hub protein
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.89   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.89   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999997012
p_ni:  0.000002988
Score:  0.234
Data Source:  BioPlex,STRINGDB
SPEM1
Tdark
Novelty:  0.28276021
p_int:  0.999993648
p_ni:  0.000006348
p_wrong:  4e-9
Score:  0.295
Data Source:  BioPlex,STRINGDB
ZPBP2
Tbio
Novelty:  0.06726687
p_int:  0.999942241
p_ni:  0.000043562
p_wrong:  0.000014197
Score:  0.188
Data Source:  BioPlex,STRINGDB
RRAGA
Tbio
Novelty:  0.02022668
p_int:  0.999915857
p_ni:  0.000083758
p_wrong:  3.85e-7
Score:  0.247
Data Source:  BioPlex,STRINGDB
SLC25A11
Tbio
Family:  Transporter
Novelty:  0.06125899
p_int:  0.999895614
p_ni:  0.00008765
p_wrong:  0.000016736
Score:  0.189
Data Source:  BioPlex,STRINGDB
PRMT6
Tchem
Family:  Epigenetic
Novelty:  0.01734208
p_int:  0.996389898
p_ni:  0.002946775
p_wrong:  0.000663327
Score:  0.183
Data Source:  BioPlex,STRINGDB
JMY
Tbio
Novelty:  0.01850088
p_int:  0.995506133
p_ni:  0.004296832
p_wrong:  0.000197036
Score:  0.349
Data Source:  BioPlex,STRINGDB
FGL1
Tbio
Novelty:  0.02650803
p_int:  0.986347376
p_ni:  0.012644249
p_wrong:  0.001008376
Data Source:  BioPlex
ACTA2
Tbio
Novelty:  0.00199354
p_int:  0.801258906
p_ni:  0.198741094
Data Source:  BioPlex
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.9
Data Source:  STRINGDB
Nearest Tclin Targets (9)
Explore Nearest Tclin Targets
1 – 3 of 3
CALM3
Tclin
Family:  Other
KEGG Distance:  2
Common Pathways:  2
CALM1
Tclin
Family:  Other
KEGG Distance:  2
Common Pathways:  2
CALM2
Tclin
Family:  Other
KEGG Distance:  2
Common Pathways:  2
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 1A
VGNC:5543
747187
Macaque
protein phosphatase 1 regulatory inhibitor subunit 1A
574202
Mouse
MGI:1889595
58200
Rat
RGD:62018
58977
Horse
protein phosphatase 1 regulatory inhibitor subunit 1A [Source:HGNC Symbol;Acc:HGNC:9286]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 1A
Macaque
protein phosphatase 1 regulatory inhibitor subunit 1A
Mouse
Rat
Horse
protein phosphatase 1 regulatory inhibitor subunit 1A [Source:HGNC Symbol;Acc:HGNC:9286]
Publication Statistics
PubMed Score 57.89
PubMed score by year
PubTator Score 446.75
PubTator score by year
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Related Publications
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PMID
Year
Title