Tbio PPP1R18 Phostensin

Protein Summary

Description

Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton. Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton. Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q6NYC8
• A2AB01
• A2AIB8
• A4UBI6
• A6NCB7
• A8MSS7
• B7ZCV7
• Q68CK8
• Q6ZTV1
• Q6ZUJ6
• Q8NDQ4
• Q8TF52
• Q9BRL9

Gene Name

• PPP1R18

Ensembl ID

• ENST00000274853
• ENSP00000274853
• ENSG00000146112
• ENST00000383573
• ENSP00000373067
• ENSG00000206485
• ENST00000399199
• ENSP00000382150
• ENST00000400554
• ENSP00000383400
• ENST00000437121
• ENSP00000405234
• ENSG00000225060
• ENST00000438815
• ENSP00000413596
• ENSG00000230341
• ENST00000438945
• ENSP00000400990
• ENSG00000234000
• ENST00000443517
• ENSP00000404066
• ENSG00000229998
• ENST00000444206
• ENSP00000416648
• ENST00000449705
• ENSP00000388790
• ENST00000451544
• ENSP00000400129
• ENST00000455935
• ENSP00000412456
• ENST00000548255
• ENSP00000446851
• ENSG00000231247
• ENST00000615527
• ENSP00000480270
• ENST00000615892
• ENSP00000482578

Symbol

• HKMT1098
• KIAA1949
• HKMT1098
• KIAA1949

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
ligand (protein) perturbation	0.83
virus perturbation	0.59
tissue	0.52
cell type or tissue	0.51

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 107   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0