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Tbio
PPP1R18
Phostensin

Protein Summary
Description
Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton. Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton. Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274853
  • ENSP00000274853
  • ENSG00000146112
  • ENST00000383573
  • ENSP00000373067
  • ENSG00000206485
  • ENST00000399199
  • ENSP00000382150
  • ENST00000400554
  • ENSP00000383400
  • ENST00000437121
  • ENSP00000405234
  • ENSG00000225060
  • ENST00000438815
  • ENSP00000413596
  • ENSG00000230341
  • ENST00000438945
  • ENSP00000400990
  • ENSG00000234000
  • ENST00000443517
  • ENSP00000404066
  • ENSG00000229998
  • ENST00000444206
  • ENSP00000416648
  • ENST00000449705
  • ENSP00000388790
  • ENST00000451544
  • ENSP00000400129
  • ENST00000455935
  • ENSP00000412456
  • ENST00000548255
  • ENSP00000446851
  • ENSG00000231247
  • ENST00000615527
  • ENSP00000480270
  • ENST00000615892
  • ENSP00000482578

Symbol
  • HKMT1098
  • KIAA1949
  • HKMT1098
  • KIAA1949
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
ligand (protein) perturbation
0.83
virus perturbation
0.59
tissue
0.52
cell type or tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.24   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0