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Tbio
PPP1R18
Phostensin

Protein Summary
Description
Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton. Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton. Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274853
  • ENSP00000274853
  • ENSG00000146112
  • ENST00000383573
  • ENSP00000373067
  • ENSG00000206485
  • ENST00000399199
  • ENSP00000382150
  • ENST00000400554
  • ENSP00000383400
  • ENST00000437121
  • ENSP00000405234
  • ENSG00000225060
  • ENST00000438815
  • ENSP00000413596
  • ENSG00000230341
  • ENST00000438945
  • ENSP00000400990
  • ENSG00000234000
  • ENST00000443517
  • ENSP00000404066
  • ENSG00000229998
  • ENST00000444206
  • ENSP00000416648
  • ENST00000449705
  • ENSP00000388790
  • ENST00000451544
  • ENSP00000400129
  • ENST00000455935
  • ENSP00000412456
  • ENST00000548255
  • ENSP00000446851
  • ENSG00000231247
  • ENST00000615527
  • ENSP00000480270
  • ENST00000615892
  • ENSP00000482578

Symbol
  • HKMT1098
  • KIAA1949
  • HKMT1098
  • KIAA1949
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.91
ligand (protein) perturbation
0.83
virus perturbation
0.59
tissue
0.52
cell type or tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.68   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.68   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  1
Score:  0.967
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  1
Score:  0.402
Data Source:  BioPlex,STRINGDB
RASIP1
Tbio
Novelty:  0.07135021
p_int:  0.999998868
p_wrong:  0.000001132
Score:  0.524
Data Source:  BioPlex,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
p_int:  0.982840714
p_ni:  0.017159286
Score:  0.869
Data Source:  BioPlex,STRINGDB
PCBP3
Tbio
Novelty:  0.11681812
p_int:  0.965001493
p_ni:  0.02823593
p_wrong:  0.006762576
Score:  0.165
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.921319436
p_ni:  0.078680564
Score:  0.354
Data Source:  BioPlex,STRINGDB
OGA
Tchem
Family:  Enzyme
Novelty:  0.00035723
p_int:  0.892540293
p_ni:  0.107459705
p_wrong:  1e-9
Score:  0.243
Data Source:  BioPlex,STRINGDB
MRPS18B
Tbio
Novelty:  0.14519418
Score:  0.719
Data Source:  STRINGDB
PRR3
Tdark
Novelty:  0.71308048
Score:  0.621
Data Source:  STRINGDB
B3GALT4
Tbio
Family:  Enzyme
Novelty:  0.02308443
Score:  0.592
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
TYROBP Causal Network
WikiPathways
TYROBP Causal Network
WikiPathways
Cytokines and Inflammatory Response
WikiPathways
T-Cell antigen Receptor (TCR) Signaling Pathway
WikiPathways
Viral Acute Myocarditis
Name
Explore in Pharos
Explore in Source
TYROBP Causal Network
TYROBP Causal Network
Cytokines and Inflammatory Response
T-Cell antigen Receptor (TCR) Signaling Pathway
Viral Acute Myocarditis
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (105)
Items per page:
1 – 5 of 105
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
2
2
0
1.1
85.8
Items per page:
1 – 5 of 105
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
0
1.1
85.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 18
VGNC:11184
743369
Macaque
protein phosphatase 1 regulatory subunit 18
712176
Mouse
MGI:1923698
76448
Rat
RGD:1309543
361790
Dog
nurim
100856242
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 18
Macaque
protein phosphatase 1 regulatory subunit 18
Mouse
Rat
Dog
nurim
Publication Statistics
PubMed Score 8.68
PubMed score by year
PubTator Score 7.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title