Protein Summary
Isoform 1: May target protein phosphatase 1 to F-actin cytoskeleton. Isoform 4: May target protein phosphatase 1 to F-actin cytoskeleton. Protein phosphatase-1 (PP1; see MIM 176875) interacts with regulatory subunits that target the enzyme to different cellular locations and change its activity toward specific substrates. Phostensin is a regulatory subunit that targets PP1 to F-actin (see MIM 102610) cytoskeleton (Kao et al., 2007 [PubMed 17374523]).[supplied by OMIM, Mar 2008]
- ENST00000274853
- ENSP00000274853
- ENSG00000146112
- ENST00000383573
- ENSP00000373067
- ENSG00000206485
- ENST00000399199
- ENSP00000382150
- ENST00000400554
- ENSP00000383400
- ENST00000437121
- ENSP00000405234
- ENSG00000225060
- ENST00000438815
- ENSP00000413596
- ENSG00000230341
- ENST00000438945
- ENSP00000400990
- ENSG00000234000
- ENST00000443517
- ENSP00000404066
- ENSG00000229998
- ENST00000444206
- ENSP00000416648
- ENST00000449705
- ENSP00000388790
- ENST00000451544
- ENSP00000400129
- ENST00000455935
- ENSP00000412456
- ENST00000548255
- ENSP00000446851
- ENSG00000231247
- ENST00000615527
- ENSP00000480270
- ENST00000615892
- ENSP00000482578
- HKMT1098
- KIAA1949
- HKMT1098
- KIAA1949
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
kinase perturbation | 0.91 | ||
ligand (protein) perturbation | 0.83 | ||
virus perturbation | 0.59 | ||
tissue | 0.52 | ||
cell type or tissue | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.68 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 107 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 8.68 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 107 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
RASIP1
Novelty: 0.07135021
p_int: 0.999998868
p_wrong: 0.000001132
Score: 0.524
Data Source: BioPlex,STRINGDB
PPP1CB
Family: Enzyme
Novelty: 0.0122614
p_int: 0.982840714
p_ni: 0.017159286
Score: 0.869
Data Source: BioPlex,STRINGDB
PCBP3
Novelty: 0.11681812
p_int: 0.965001493
p_ni: 0.02823593
p_wrong: 0.006762576
Score: 0.165
Data Source: BioPlex,STRINGDB
GSN
Novelty: 0.00060852
p_int: 0.921319436
p_ni: 0.078680564
Score: 0.354
Data Source: BioPlex,STRINGDB
OGA
Family: Enzyme
Novelty: 0.00035723
p_int: 0.892540293
p_ni: 0.107459705
p_wrong: 1e-9
Score: 0.243
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (6)
WikiPathways (6)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
WikiPathways | TYROBP Causal Network | ||||
WikiPathways | TYROBP Causal Network | ||||
WikiPathways | Cytokines and Inflammatory Response | ||||
WikiPathways | T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
WikiPathways | Viral Acute Myocarditis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
TYROBP Causal Network | ||||
TYROBP Causal Network | ||||
Cytokines and Inflammatory Response | ||||
T-Cell antigen Receptor (TCR) Signaling Pathway | ||||
Viral Acute Myocarditis | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (2)
Components (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (105)
Items per page:
1 – 5 of 105
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
2 | 2 | 0 | 1.1 | 85.8 | ||||||
Items per page:
1 – 5 of 105
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
0 | 1.1 | 85.8 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | protein phosphatase 1 regulatory subunit 18 | VGNC:11184 | 743369 | |||||
Macaque | protein phosphatase 1 regulatory subunit 18 | 712176 | ||||||
Mouse | MGI:1923698 | 76448 | ||||||
Rat | RGD:1309543 | 361790 | ||||||
Dog | nurim | 100856242 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | protein phosphatase 1 regulatory subunit 18 | |||||
Macaque | protein phosphatase 1 regulatory subunit 18 | |||||
Mouse | ||||||
Rat | ||||||
Dog | nurim | |||||
Publication Statistics
PubMed Score 8.68
PubMed score by year
PubTator Score 7.13
PubTator score by year
Related Publications
Text Mined References (19)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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