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Tbio
PPP1R14C
Protein phosphatase 1 regulatory subunit 14C

Protein Summary
Description
Inhibitor of the PP1 regulatory subunit PPP1CA. The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]).[supplied by OMIM, Feb 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000361131
  • ENSP00000355260
  • ENSG00000198729

Symbol
  • KEPI
  • KEPI
  • NY-BR-81
  • CPI17-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
histone modification site profile
0.59
PubMedID
0.59
cell type or tissue
0.57
gene perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.01   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 26.01   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
p_int:  0.999521064
p_ni:  0.000469328
p_wrong:  0.000009608
Score:  0.379
Data Source:  BioPlex,STRINGDB
HMGCS1
Tchem
Family:  Enzyme
Novelty:  0.01089288
p_int:  0.86025873
p_ni:  0.139736986
p_wrong:  0.000004284
Score:  0.309
Data Source:  BioPlex,STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.951
Data Source:  STRINGDB
PPP1R14D
Tbio
Family:  Enzyme
Novelty:  0.0782199
Score:  0.803
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.716
Data Source:  STRINGDB
ZFHX3
Tbio
Family:  TF
Novelty:  0.00996692
Score:  0.707
Data Source:  STRINGDB
TCP1
Tbio
Novelty:  0.00395241
Score:  0.701
Data Source:  STRINGDB
LRP11
Tdark
Novelty:  0.22784094
Score:  0.634
Data Source:  STRINGDB
SPATA25
Tbio
Novelty:  0.80142563
Score:  0.62
Data Source:  STRINGDB
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.606
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 14C
VGNC:3667
735727
Macaque
protein phosphatase 1 regulatory inhibitor subunit 14C
713335
Mouse
MGI:1923392
76142
Rat
RGD:620538
171010
Cow
protein phosphatase 1 regulatory inhibitor subunit 14C
VGNC:33227
617148
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory inhibitor subunit 14C
Macaque
protein phosphatase 1 regulatory inhibitor subunit 14C
Mouse
Rat
Cow
protein phosphatase 1 regulatory inhibitor subunit 14C
Publication Statistics
PubMed Score 26.01
PubMed score by year
PubTator Score 40.47
PubTator score by year
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Related Publications
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PMID
Year
Title