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Tbio
PPP1R14A
Protein phosphatase 1 regulatory subunit 14A

Protein Summary
Description
Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction. The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301242
  • ENSP00000301242
  • ENSG00000167641
  • ENST00000347262
  • ENSP00000301243

Symbol
  • CPI17
  • PPP1INL
  • CPI17
  • CPI-17
  • PPP1INL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
1
hub protein
0.71
transcription factor
0.71
biological term
0.68
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.36   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 413.36   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (66)
RIOK1
Tchem
Family:  Kinase
Novelty:  0.02476698
p_int:  0.999226335
p_ni:  0.000773657
p_wrong:  9e-9
Data Source:  BioPlex
WDR77
Tbio
Novelty:  0.03052382
p_int:  0.983136457
p_ni:  0.016863543
Data Source:  BioPlex
PRMT5
Tchem
Family:  Epigenetic
Novelty:  0.00395474
p_int:  0.973998194
p_ni:  0.026001806
Data Source:  BioPlex
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.982
Data Source:  Reactome,STRINGDB
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
Score:  0.972
Data Source:  STRINGDB
ILK
Tchem
Family:  Kinase
Novelty:  0.00147344
Score:  0.952
Data Source:  STRINGDB
ROCK1
Tclin
Family:  Kinase
Novelty:  0.00156045
Score:  0.951
Data Source:  STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
Score:  0.946
Data Source:  Reactome,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.937
Data Source:  Reactome,STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (24)
RHO GTPase Effectors (R-HSA-195258)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RHO GTPase Effectors
Reactome
RHO GTPases activate PKNs
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
RHO GTPase Effectors
RHO GTPases activate PKNs
Signal Transduction
Signaling by Rho GTPases
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
3
0
1.1
92.5
platelet count
2
2
2
85.2
calcium measurement
1
1
1
63.7
serum gamma-glutamyl transferase measurement
1
1
1
59
mean platelet volume
1
1
1
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
92.5
platelet count
2
85.2
calcium measurement
1
63.7
serum gamma-glutamyl transferase measurement
1
59
mean platelet volume
1
51.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 14A
719523
Mouse
MGI:1931139
68458
Rat
RGD:620536
114004
Dog
protein phosphatase 1 regulatory inhibitor subunit 14A
VGNC:53753
612579
Horse
protein phosphatase 1 regulatory inhibitor subunit 14A
VGNC:21758
100629152
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 14A
Mouse
Rat
Dog
protein phosphatase 1 regulatory inhibitor subunit 14A
Horse
protein phosphatase 1 regulatory inhibitor subunit 14A
Publication Statistics
PubMed Score 413.36
PubMed score by year
PubTator Score 61.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title