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Tbio
PPP1R13L
RelA-associated inhibitor

Protein Summary
Description
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis. IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53.[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360957
  • ENSP00000354218
  • ENSG00000104881
  • ENST00000418234
  • ENSP00000403902

Symbol
  • IASPP
  • NKIP1
  • PPP1R13BL
  • RAI
  • RAI
  • RAI4
  • IASPP
  • NKIP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.83
biological process
0.74
transcription factor
0.74
histone modification site profile
0.73
tissue sample
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.74   (req: < 5)
Gene RIFs: 87   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.74   (req: >= 5)
Gene RIFs: 87   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999992
p_ni:  1e-9
p_wrong:  7e-9
Score:  0.327
Data Source:  BioPlex,STRINGDB
MAGEA4
Tbio
Novelty:  0.00949096
p_int:  0.999999726
p_ni:  2.74e-7
Score:  0.189
Data Source:  BioPlex,STRINGDB
TAX1BP3
Tbio
Novelty:  0.01605171
p_int:  0.999999462
p_ni:  5.38e-7
Data Source:  BioPlex
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999996407
p_ni:  0.000003593
Score:  0.35
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999984544
p_ni:  0.000015451
p_wrong:  5e-9
Data Source:  BioPlex
MAPRE1
Tbio
Novelty:  0.01267772
p_int:  0.999965789
p_ni:  0.000034211
Score:  0.232
Data Source:  BioPlex,STRINGDB
PPP1R12B
Tbio
Family:  Enzyme
Novelty:  0.0424259
p_int:  0.995445381
p_ni:  0.004554618
Data Source:  BioPlex
FAM19A3
Tdark
Novelty:  0.37183557
p_int:  0.993868015
p_ni:  0.002383311
p_wrong:  0.003748675
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.987
Data Source:  Reactome,STRINGDB
TP73
Tbio
Family:  TF
Novelty:  0.00667737
Score:  0.962
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
Regulation of TP53 Activity
Reactome
Regulation of TP53 Activity through Association with Co-factors
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Regulation of TP53 Activity
Regulation of TP53 Activity through Association with Co-factors
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
4
4
7
98.4
heel bone mineral density
3
4
6
91.1
apolipoprotein B measurement
1
7
7
89.6
low density lipoprotein cholesterol measurement
1
4
4
80.3
response to statin
1
1
1
66
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
creatine kinase measurement
7
98.4
heel bone mineral density
6
91.1
apolipoprotein B measurement
7
89.6
low density lipoprotein cholesterol measurement
4
80.3
response to statin
1
66
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 13 like
VGNC:3620
456126
Mouse
MGI:3525053
333654
Rat
RGD:1593681
686781
Dog
protein phosphatase 1 regulatory subunit 13 like
VGNC:44882
612286
Horse
protein phosphatase 1 regulatory subunit 13 like
VGNC:51063
100146706
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 13 like
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 13 like
Horse
protein phosphatase 1 regulatory subunit 13 like
Publication Statistics
PubMed Score 98.74
PubMed score by year
PubTator Score 66.44
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title