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Tbio
PPP1R13B
Apoptosis-stimulating of p53 protein 1

Protein Summary
Description
Regulator that plays a central role in regulation of apoptosis via its interaction with p53/TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. ASPP proteins are required for the induction of apoptosis by p53-family proteins. They promote DNA binding and transactivation of p53-family proteins on the promoters of proapoptotic genes. Expression of this gene is regulated by the E2F transcription factor. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000202556
  • ENSP00000202556
  • ENSG00000088808

Symbol
  • ASPP1
  • KIAA0771
  • p85
  • ASPP1
  • p53BP2-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
disease perturbation
0.74
protein domain
0.73
tissue sample
0.72
microRNA
0.63


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.6   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.6   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (53)
CCDC85B
Tdark
Novelty:  0.02034018
p_int:  0.999999812
p_ni:  1.88e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.999999799
p_ni:  2.01e-7
Score:  0.196
Data Source:  BioPlex,STRINGDB
RASSF8
Tbio
Novelty:  0.09245647
p_int:  0.999999795
p_ni:  2.05e-7
Score:  0.852
Data Source:  BioPlex,STRINGDB
IFFO2
Tdark
Novelty:  2.08798116
p_int:  0.999998673
p_ni:  0.000001319
p_wrong:  8e-9
Data Source:  BioPlex
IFFO1
Tdark
Novelty:  0.38051741
p_int:  0.999995668
p_ni:  0.000004332
Data Source:  BioPlex
GSTM3
Tbio
Family:  Enzyme
Novelty:  0.0078192
p_int:  0.999977834
p_ni:  0.000006629
p_wrong:  0.000015537
Score:  0.189
Data Source:  BioPlex,STRINGDB
RASSF7
Tbio
Novelty:  0.08011259
p_int:  0.999906065
p_ni:  0.000011758
p_wrong:  0.000082178
Score:  0.796
Data Source:  BioPlex,STRINGDB
ODF2L
Tdark
Novelty:  0.56986705
p_int:  0.999875979
p_ni:  0.000019641
p_wrong:  0.000104379
Data Source:  BioPlex
SRGAP3
Tbio
Family:  Enzyme
Novelty:  0.01913784
p_int:  0.999847264
p_ni:  0.000152736
Score:  0.267
Data Source:  BioPlex,STRINGDB
CEP250
Tbio
Novelty:  0.08014712
p_int:  0.999757654
p_ni:  0.000242346
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (16)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of PUMA and translocation to mitochondria
Apoptosis
Gene expression (Transcription)
Generic Transcription Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
2
1.1
80.5
sex hormone-binding globulin measurement
4
1
4
75
body mass index
5
1
5
71
heel bone mineral density
1
1
1
67.9
smoking behaviour measurement
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.1
80.5
sex hormone-binding globulin measurement
4
75
body mass index
5
71
heel bone mineral density
1
67.9
smoking behaviour measurement
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 13B
VGNC:3355
453193
Macaque
protein phosphatase 1 regulatory subunit 13B
700432
Mouse
MGI:1336199
21981
Rat
RGD:1304651
314465
Dog
protein phosphatase 1 regulatory subunit 13B
VGNC:44881
490874
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 13B
Macaque
protein phosphatase 1 regulatory subunit 13B
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 13B
Publication Statistics
PubMed Score 24.60
PubMed score by year
PubTator Score 22.93
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title