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Tdark
PPP1R12C
Protein phosphatase 1 regulatory subunit 12C

Protein Summary
Description
Regulates myosin phosphatase activity. The gene encodes a subunit of myosin phosphatase. The encoded protein regulates the catalytic activity of protein phosphatase 1 delta and assembly of the actin cytoskeleton. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263433
  • ENSP00000263433
  • ENSG00000125503
  • ENST00000435544
  • ENSP00000387833

Symbol
  • LENG3
  • MBS85
  • p84
  • p85
  • AAVS1
  • LENG3
  • MBS85
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.75
transcription factor
0.69
transcription factor binding site profile
0.67
histone modification site profile
0.64
tissue
0.51


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.11   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 50   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.11   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 50   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
JPH4
Tbio
Novelty:  0.07699598
p_int:  0.999998841
p_ni:  4.3e-8
p_wrong:  0.000001116
Score:  0.159
Data Source:  BioPlex,STRINGDB
COL9A1
Tbio
Novelty:  0.0160066
p_int:  0.999995401
p_ni:  4.7e-8
p_wrong:  0.000004552
Score:  0.507
Data Source:  BioPlex,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.983
Data Source:  STRINGDB
MYL9
Tbio
Novelty:  0.00309239
Score:  0.945
Data Source:  STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
Score:  0.935
Data Source:  STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
Score:  0.921
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.913
Data Source:  STRINGDB
PPP1R12A
Tbio
Family:  Enzyme
Novelty:  0.0028297
Score:  0.91
Data Source:  STRINGDB
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
Score:  0.862
Data Source:  STRINGDB
PPP1R14A
Tbio
Family:  Enzyme
Novelty:  0.00231198
Score:  0.844
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (18)
Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Focal adhesion
KEGG
Oxytocin signaling pathway
KEGG
Regulation of actin cytoskeleton
KEGG
Vascular smooth muscle contraction
KEGG
Proteoglycans in cancer
Name
Explore in Pharos
Explore in Source
Focal adhesion
Oxytocin signaling pathway
Regulation of actin cytoskeleton
Vascular smooth muscle contraction
Proteoglycans in cancer
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
3
4
97.4
reticulocyte count
4
3
5
94.1
reticulocyte measurement
2
2
3
90.9
platelet crit
2
4
5
90.3
mean corpuscular volume
1
4
4
89
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.4
reticulocyte count
5
94.1
reticulocyte measurement
3
90.9
platelet crit
5
90.3
mean corpuscular volume
4
89
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 12C
VGNC:12062
456295
Macaque
protein phosphatase 1 regulatory subunit 12C
698538
Mouse
MGI:1924258
232807
Rat
RGD:1584883
499076
Dog
protein phosphatase 1 regulatory subunit 12C
VGNC:44880
100683226
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 12C
Macaque
protein phosphatase 1 regulatory subunit 12C
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 12C
Publication Statistics
PubMed Score 237.11
PubMed score by year
PubTator Score 14.84
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title