Tbio PPP1R11 E3 ubiquitin-protein ligase PPP1R11

Protein Summary

Description

Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O60927

Gene Name

• PPP1R11

Ensembl ID

• ENST00000376772
• ENSP00000365963
• ENSG00000204619
• ENST00000383612
• ENSP00000373107
• ENSG00000206501
• ENST00000431424
• ENSP00000411038
• ENSG00000236560
• ENST00000431977
• ENSP00000407981
• ENSG00000237829
• ENST00000436591
• ENSP00000414808
• ENSG00000234058
• ENST00000437937
• ENSP00000394056
• ENSG00000233314
• ENST00000448378
• ENSP00000403557
• ENSG00000237403
• ENST00000452679
• ENSP00000412297
• ENSG00000227720

Symbol

• HCGV
• TCTE5
• HCGV
• IPP3
• HCG-V
• TCTE5
• TCTEX5
• CFAP255

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.87
tissue sample	0.64
cell type or tissue	0.61
tissue	0.61
co-expressed gene	0.57

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / E3 Ubiquitin-protein Ligase Ppp1r11

DTO Classes

Protein / Enzyme Modulator / Phosphatase Modulator / Phosphatase Inhibitor / Protein Phosphatase 1 Regulatory Subunit 11

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.3   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 100   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.3   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0