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Tbio
PPP1R11
E3 ubiquitin-protein ligase PPP1R11

Protein Summary
Description
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376772
  • ENSP00000365963
  • ENSG00000204619
  • ENST00000383612
  • ENSP00000373107
  • ENSG00000206501
  • ENST00000431424
  • ENSP00000411038
  • ENSG00000236560
  • ENST00000431977
  • ENSP00000407981
  • ENSG00000237829
  • ENST00000436591
  • ENSP00000414808
  • ENSG00000234058
  • ENST00000437937
  • ENSP00000394056
  • ENSG00000233314
  • ENST00000448378
  • ENSP00000403557
  • ENSG00000237403
  • ENST00000452679
  • ENSP00000412297
  • ENSG00000227720

Symbol
  • HCGV
  • TCTE5
  • HCGV
  • IPP3
  • HCG-V
  • TCTE5
  • TCTEX5
  • CFAP255
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
tissue sample
0.64
cell type or tissue
0.61
tissue
0.61
co-expressed gene
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0