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Tbio
PPP1R11
E3 ubiquitin-protein ligase PPP1R11

Protein Summary
Description
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2 (PubMed:27805901). Inhibitor of protein phosphatase 1 (PubMed:9843442). This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376772
  • ENSP00000365963
  • ENSG00000204619
  • ENST00000383612
  • ENSP00000373107
  • ENSG00000206501
  • ENST00000431424
  • ENSP00000411038
  • ENSG00000236560
  • ENST00000431977
  • ENSP00000407981
  • ENSG00000237829
  • ENST00000436591
  • ENSP00000414808
  • ENSG00000234058
  • ENST00000437937
  • ENSP00000394056
  • ENSG00000233314
  • ENST00000448378
  • ENSP00000403557
  • ENSG00000237403
  • ENST00000452679
  • ENSP00000412297
  • ENSG00000227720

Symbol
  • HCGV
  • TCTE5
  • HCGV
  • IPP3
  • HCG-V
  • TCTE5
  • TCTEX5
  • CFAP255
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
tissue sample
0.64
cell type or tissue
0.61
tissue
0.61
co-expressed gene
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.96   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.96   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (139)
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999999996
p_ni:  1e-9
p_wrong:  3e-9
Score:  0.958
Data Source:  BioPlex,STRINGDB
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999606
p_ni:  2e-9
p_wrong:  3.93e-7
Score:  0.951
Data Source:  BioPlex,STRINGDB
UBXN2A
Tbio
Novelty:  0.52282698
p_int:  0.999987517
p_ni:  0.000012221
p_wrong:  2.62e-7
Score:  0.586
Data Source:  BioPlex,STRINGDB
UBXN2B
Tbio
Novelty:  0.67291382
p_int:  0.860346607
p_ni:  0.000032023
p_wrong:  0.13962137
Score:  0.586
Data Source:  BioPlex,STRINGDB
PPP1CB
Tbio
Family:  Enzyme
Novelty:  0.0122614
Score:  0.989
Data Source:  STRINGDB
PPP1R2
Tbio
Family:  Enzyme
Novelty:  0.02581522
Score:  0.982
Data Source:  STRINGDB
PPP1R7
Tbio
Family:  Enzyme
Novelty:  0.02088568
Score:  0.957
Data Source:  STRINGDB
PPA2
Tbio
Family:  Enzyme
Novelty:  0.01790138
Score:  0.825
Data Source:  STRINGDB
TRIM26
Tbio
Novelty:  0.07177119
Score:  0.798
Data Source:  STRINGDB
UTP20
Tbio
Novelty:  0.09170451
Score:  0.719
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (336)
Items per page:
1 – 5 of 336
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
reticulocyte measurement
3
9
13
99.1
Items per page:
1 – 5 of 336
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
reticulocyte measurement
13
99.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 11
712286
Mouse
MGI:1923747
76497
Rat
RGD:1303163
294207
Dog
protein phosphatase 1 regulatory inhibitor subunit 11
VGNC:44877
608919
Horse
protein phosphatase 1 regulatory inhibitor subunit 11
VGNC:21754
100051847
Species
Name
OMA
EggNOG
Inparanoid
Macaque
protein phosphatase 1 regulatory inhibitor subunit 11
Mouse
Rat
Dog
protein phosphatase 1 regulatory inhibitor subunit 11
Horse
protein phosphatase 1 regulatory inhibitor subunit 11
Publication Statistics
PubMed Score 13.96
PubMed score by year
PubTator Score 21.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title