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Tbio
PPP1R10
Serine/threonine-protein phosphatase 1 regulatory subunit 10

Protein Summary
Description
Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers (By similarity). This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376511
  • ENSP00000365694
  • ENSG00000204569
  • ENST00000383586
  • ENSP00000373080
  • ENSG00000206489
  • ENST00000420949
  • ENSP00000413554
  • ENSG00000230995
  • ENST00000424446
  • ENSP00000407181
  • ENSG00000231737
  • ENST00000426299
  • ENSP00000389299
  • ENSG00000235291
  • ENST00000429597
  • ENSP00000407310
  • ENSG00000238104
  • ENST00000449113
  • ENSP00000416060
  • ENSG00000227804

Symbol
  • CAT53
  • FB19
  • PNUTS
  • p99
  • FB19
  • R111
  • CAT53
  • PNUTS
  • PP1R10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
drug perturbation
0.71
cell line
0.66
microRNA
0.65
molecular function
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.89   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.89   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (106)
PPP1CC
Tchem
Family:  Enzyme
Novelty:  0.00465946
p_int:  0.999999924
p_ni:  7.4e-8
p_wrong:  2e-9
Score:  0.973
Data Source:  BioPlex,STRINGDB
TOX4
Tbio
Family:  TF
Novelty:  0.02486844
p_int:  0.999999849
p_ni:  1.49e-7
p_wrong:  2e-9
Score:  0.889
Data Source:  BioPlex,STRINGDB
PPP1CA
Tchem
Family:  Enzyme
Novelty:  0.00354658
p_int:  0.999995539
p_ni:  6.8e-8
p_wrong:  0.000004393
Score:  0.985
Data Source:  BioPlex,STRINGDB
CAPN13
Tdark
Novelty:  0.27206398
p_int:  0.999994262
p_ni:  0.000005737
p_wrong:  1e-9
Score:  0.182
Data Source:  BioPlex,STRINGDB
ZFP41
Tdark
Family:  TF
Novelty:  3.33093006
p_int:  0.999876092
p_ni:  0.000123736
p_wrong:  1.72e-7
Data Source:  BioPlex
FURIN
Tchem
Family:  Enzyme
Novelty:  0.00055079
p_int:  0.999839567
p_ni:  0.000160433
Data Source:  BioPlex
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.996473763
p_ni:  0.002819961
p_wrong:  0.000706276
Data Source:  BioPlex
RSPH9
Tbio
Novelty:  0.08651313
p_int:  0.996463022
p_ni:  0.003535104
p_wrong:  0.000001874
Score:  0.2
Data Source:  BioPlex,STRINGDB
MMP26
Tchem
Family:  Enzyme
Novelty:  0.02180874
p_int:  0.994670196
p_ni:  0.005294321
p_wrong:  0.000035483
Score:  0.173
Data Source:  BioPlex,STRINGDB
COPZ1
Tbio
Novelty:  0.01405958
p_int:  0.969157347
p_ni:  0.030842574
p_wrong:  7.9e-8
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (154)
Items per page:
1 – 5 of 154
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
1.2
74.7
1
2
0
1.2
74.7
1
2
0
1.2
74.7
1
2
0
1.2
74.7
1
2
0
1.2
74.7
Items per page:
1 – 5 of 154
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
74.7
0
1.2
74.7
0
1.2
74.7
0
1.2
74.7
0
1.2
74.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 10
VGNC:11180
462544
Macaque
protein phosphatase 1 regulatory subunit 10
711949
Mouse
MGI:1289273
52040
Rat
RGD:620079
65045
Dog
protein phosphatase 1 regulatory subunit 10
VGNC:44876
481705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase 1 regulatory subunit 10
Macaque
protein phosphatase 1 regulatory subunit 10
Mouse
Rat
Dog
protein phosphatase 1 regulatory subunit 10
Publication Statistics
PubMed Score 96.89
PubMed score by year
PubTator Score 68.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title