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Tbio
PPP1CB
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

Protein Summary
Description
Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). The pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296122
  • ENSP00000296122
  • ENSG00000213639
  • ENST00000358506
  • ENSP00000351298
  • ENST00000395366
  • ENSP00000378769

Symbol
  • PP1B
  • NSLH2
  • PP-1B
  • PPP1CD
  • PP1beta
  • HEL-S-80p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.92
transcription factor binding site profile
0.89
virus perturbation
0.88
kinase perturbation
0.84
biological process
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.39   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 461   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.39   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 461   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0