Tchem PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

Protein Summary

Description

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Dephosphorylates CENPA (PubMed:25556658). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (PubMed:26083323). The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P62136
• A6NNR3
• B2R908
• P08129
• P20653
• P22802
• Q07161
• PP-1A

Gene Name

• PPP1CA

Ensembl ID

• ENST00000312989
• ENSP00000326031
• ENSG00000172531
• ENST00000358239
• ENSP00000350974
• ENST00000376745
• ENSP00000365936

Symbol

• PPP1A
• PP1A
• PP-1A
• PPP1A
• PP1alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	1
interacting protein	1
kinase perturbation	0.96
disease perturbation	0.95
biological process	0.9

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase Pp1-alpha Catalytic Subunit

Protein / Calcium-binding Protein / Serine/threonine-protein Phosphatase Pp1-alpha Catalytic Subunit

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Protein Phosphatase / Serine/threonine-protein Phosphatase Pp1-alpha Catalytic Subunit

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.29   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 542   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.29   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 542   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0