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Tbio
PPM1L
Protein phosphatase 1L

Protein Summary
Description
Acts as a suppressor of the SAPK signaling pathways by associating with and dephosphorylating MAP3K7/TAK1 and MAP3K5, and by attenuating the association between MAP3K7/TAK1 and MAP2K4 or MAP2K6. The protein encoded by this gene is a magnesium or manganese-requiring phosphatase that is involved in several signaling pathways. The encoded protein downregulates apoptosis signal-regulating kinase 1, a protein that initiates a signaling cascade that leads to apoptosis when cells are subjected to cytotoxic stresses. This protein also is an endoplasmic reticulum transmembrane protein that helps regulate ceramide transport from the endoplasmic reticulum to the Golgi apparatus. Finally, this gene may be involved in adiposity since it is upregulated in adipose tissues. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295839
  • ENSP00000295839
  • ENSG00000163590
  • ENST00000464260
  • ENSP00000420746
  • ENST00000497343
  • ENSP00000420354
  • ENST00000498165
  • ENSP00000417659

Symbol
  • PP2CE
  • PP2CE
  • PPM1-LIKE
  • PP2C-epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.87
transcription factor binding site profile
0.84
transcription factor perturbation
0.84
virus perturbation
0.79
small molecule perturbation
0.75


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.62   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
RXFP1
Tchem
Family:  GPCR
Novelty:  0.00580827
p_int:  0.999511041
p_ni:  0.000288257
p_wrong:  0.000200703
Data Source:  BioPlex
TDRD10
Tdark
Family:  Epigenetic
Novelty:  0.59172141
p_int:  0.997062137
p_ni:  1e-8
p_wrong:  0.002937854
Data Source:  BioPlex
B4GAT1
Tbio
Family:  Enzyme
Novelty:  0.14959923
p_int:  0.994475793
p_ni:  0.00306622
p_wrong:  0.002457987
Score:  0.214
Data Source:  BioPlex,STRINGDB
ITPA
Tbio
Family:  Enzyme
Novelty:  0.00235169
p_int:  0.982355557
p_ni:  0.016183399
p_wrong:  0.001461045
Data Source:  BioPlex
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
Score:  0.939
Data Source:  STRINGDB
VAPA
Tbio
Novelty:  0.00169209
Score:  0.921
Data Source:  Reactome,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
Score:  0.909
Data Source:  Reactome,STRINGDB
OSBP
Tbio
Novelty:  0.00425747
Score:  0.903
Data Source:  STRINGDB
LACTB
Tbio
Family:  Enzyme
Novelty:  0.02200752
Score:  0.74
Data Source:  STRINGDB
PPP5C
Tbio
Family:  Enzyme
Novelty:  0.01990823
Score:  0.682
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (38)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
3
1
1
80.2
self reported educational attainment
2
2
2
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
80.2
self reported educational attainment
2
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1L
VGNC:14804
742596
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1L
702049
Mouse
MGI:2139740
242083
Rat
RGD:1305220
310506
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1L
VGNC:44871
608708
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1L
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1L
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1L
Publication Statistics
PubMed Score 10.62
PubMed score by year
PubTator Score 7.15
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title