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Tbio
PPM1K
Protein phosphatase 1K, mitochondrial

Protein Summary
Description
Regulates the mitochondrial permeability transition pore and is essential for cellular survival and development. This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000608933
  • ENSP00000477341
  • ENSG00000163644

Symbol
  • PP2CM
  • BDP
  • PTMP
  • PP2Cm
  • MSUDMV
  • PP2Ckappa
  • UG0882E07
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.8
transcription factor binding site profile
0.75
microRNA
0.69
tissue
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.51   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 143   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.51   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 143   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
DBT
Tbio
Family:  Enzyme
Novelty:  0.0070589
p_int:  0.999999682
p_ni:  1.14e-7
p_wrong:  2.05e-7
Score:  0.97
Data Source:  BioPlex,Reactome,STRINGDB
BCKDHB
Tbio
Family:  Enzyme
Novelty:  0.02234969
p_int:  0.999997965
p_ni:  0.000001651
p_wrong:  3.84e-7
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
BCKDHA
Tbio
Family:  Enzyme
Novelty:  0.01684893
p_int:  0.993705969
p_ni:  0.00629403
p_wrong:  1e-9
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
DLD
Tbio
Family:  Enzyme
Novelty:  0.00214298
Score:  0.907
Data Source:  Reactome,STRINGDB
PSPH
Tbio
Family:  Enzyme
Novelty:  0.01078634
Score:  0.904
Data Source:  STRINGDB
PPTC7
Tdark
Family:  Enzyme
Novelty:  0.36770849
Score:  0.717
Data Source:  STRINGDB
FAM110B
Tbio
Novelty:  0.35516609
Score:  0.714
Data Source:  STRINGDB
HDHD5
Tdark
Novelty:  0.95671879
Score:  0.685
Data Source:  STRINGDB
BCKDK
Tbio
Family:  Kinase
Novelty:  0.03296998
Score:  0.639
Data Source:  STRINGDB
MGAM
Tclin
Family:  Enzyme
Novelty:  0.00045865
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Branched-chain amino acid catabolism (R-HSA-70895)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Branched-chain amino acid catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Branched-chain amino acid catabolism
Metabolism
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
3
8
9
99.2
amino acid measurement
4
4
5
94.1
blood metabolite measurement
2
4
6
94.1
protein measurement
1
2
2
82.9
uric acid measurement
1
1
1
81.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
9
99.2
amino acid measurement
5
94.1
blood metabolite measurement
6
94.1
protein measurement
2
82.9
uric acid measurement
1
81.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1K
VGNC:8269
461368
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1K
702398
Mouse
MGI:2442111
243382
Rat
RGD:1308501
312381
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1K
VGNC:44870
478473
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1K
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1K
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1K
Publication Statistics
PubMed Score 34.51
PubMed score by year
PubTator Score 10.27
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title