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Tbio
PPM1E
Protein phosphatase 1E

Protein Summary
Description
Protein phosphatase that inactivates multifunctional CaM kinases such as CAMK4 and CAMK2 (By similarity). Dephosphorylates and inactivates PAK. May play a role in the inhibition of actin fiber stress breakdown and in morphological changes driven by TNK2/CDC42. Dephosphorylates PRKAA2 (By similarity). This gene encodes a member of the PPM family of serine/threonine-protein phosphatases. The encoded protein is localized to the nucleus and dephosphorylates and inactivates multiple substrates including serine/threonine-protein kinase PAK 1, 5'-AMP-activated protein kinase (AMPK) and the multifunctional calcium/calmodulin-dependent protein kinases. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308249
  • ENSP00000312411
  • ENSG00000175175

Symbol
  • CAMKN
  • KIAA1072
  • POPX1
  • POPX1
  • PP2CH
  • caMKN
  • CaMKP-N
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.95
tissue sample
0.75
PubMedID
0.74
gene perturbation
0.73
microRNA
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
TRO
Tbio
Novelty:  0.02850833
p_int:  0.999794474
p_ni:  0.000205526
Score:  0.201
Data Source:  BioPlex,STRINGDB
PSMG4
Tdark
Novelty:  0.05339077
p_int:  0.997615866
p_ni:  0.002367953
p_wrong:  0.000016181
Score:  0.188
Data Source:  BioPlex,STRINGDB
PSMG3
Tchem
Novelty:  0.01730294
p_int:  0.996331652
p_ni:  0.003668319
p_wrong:  2.9e-8
Data Source:  BioPlex
PRMT2
Tbio
Family:  Epigenetic
Novelty:  0.04121581
p_int:  0.928950531
p_ni:  0.071049408
p_wrong:  6.1e-8
Score:  0.227
Data Source:  BioPlex,STRINGDB
NDUFAF5
Tbio
Family:  Enzyme
Novelty:  0.13483499
p_int:  0.928638161
p_ni:  0.071355936
p_wrong:  0.000005903
Score:  0.238
Data Source:  BioPlex,STRINGDB
BRCA2
Tbio
Novelty:  0.0002217
p_int:  0.908500271
p_ni:  0.091499729
Score:  0.201
Data Source:  BioPlex,STRINGDB
FAM83H
Tbio
Novelty:  0.02527211
p_int:  0.895752295
p_ni:  0.104247705
Data Source:  BioPlex
FAM192A
Tdark
Novelty:  0.46220707
p_int:  0.881306973
p_ni:  0.118693027
Score:  0.364
Data Source:  BioPlex,STRINGDB
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.873245101
p_ni:  0.126754899
Data Source:  BioPlex
SERPINB4
Tbio
Novelty:  0.00522283
p_int:  0.816070876
p_ni:  0.183929124
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

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Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Negative regulation of NMDA receptor-mediated neuronal transmission
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Negative regulation of NMDA receptor-mediated neuronal transmission
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Transmission across Chemical Synapses
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
3
1
7.5
88.1
systolic blood pressure
1
1
1
66.8
mean corpuscular volume
1
1
1
61.9
mean reticulocyte volume
1
1
1
58.3
neutrophil count
1
1
1
55
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
1
7.5
88.1
systolic blood pressure
1
66.8
mean corpuscular volume
1
61.9
mean reticulocyte volume
1
58.3
neutrophil count
1
55
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1E
VGNC:12600
468424
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1E
711012
Mouse
MGI:2444096
320472
Rat
RGD:735028
360593
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1E
VGNC:44865
612897
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1E
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1E
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1E
Publication Statistics
PubMed Score 10.52
PubMed score by year
PubTator Score 7.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title