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Tchem
PPM1A
Protein phosphatase 1A

Protein Summary
Description
Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325642
  • ENSP00000327255
  • ENSG00000100614
  • ENST00000325658
  • ENSP00000314850
  • ENST00000395076
  • ENSP00000378514

Symbol
  • PPPM1A
  • PP2CA
  • PP2Calpha
  • PP2C-ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
transcription factor perturbation
0.98
biological process
0.96
virus perturbation
0.96
microRNA
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.86   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.86   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (110)
PPM1B
Tchem
Family:  Enzyme
Novelty:  0.02370446
p_int:  0.999999759
p_ni:  2.41e-7
Score:  0.719
Data Source:  BioPlex,STRINGDB
INPPL1
Tchem
Family:  Enzyme
Novelty:  0.00634126
p_int:  0.999994066
p_ni:  0.000005934
Score:  0.176
Data Source:  BioPlex,STRINGDB
HAO2
Tchem
Family:  Enzyme
Novelty:  0.03029536
p_int:  0.999959923
p_ni:  0.000040077
Score:  0.176
Data Source:  BioPlex,STRINGDB
CERKL
Tbio
Family:  Enzyme
Novelty:  0.04190552
p_int:  0.999958076
p_ni:  0.000041924
Score:  0.527
Data Source:  BioPlex,STRINGDB
RNASE13
Tbio
Family:  Enzyme
Novelty:  0.05907604
p_int:  0.999741087
p_ni:  0.000258913
Score:  0.169
Data Source:  BioPlex,STRINGDB
PLA2G2D
Tchem
Family:  Enzyme
Novelty:  0.01212618
p_int:  0.999345693
p_ni:  0.0006543
p_wrong:  8e-9
Data Source:  BioPlex
PRSS22
Tdark
Family:  Enzyme
Novelty:  0.38206974
p_int:  0.998435309
p_ni:  0.001564691
Score:  0.297
Data Source:  BioPlex,STRINGDB
IL20
Tbio
Novelty:  0.78184288
p_int:  0.998006335
p_ni:  0.001924359
p_wrong:  0.000069306
Data Source:  BioPlex
GDF3
Tbio
Novelty:  0.02003647
p_int:  0.996357878
p_ni:  0.003642122
Score:  0.303
Data Source:  BioPlex,STRINGDB
TECPR2
Tbio
Novelty:  0.11606334
p_int:  0.996212983
p_ni:  0.003787016
Score:  0.187
Data Source:  BioPlex,STRINGDB
Pathways (87)
Downregulation of SMAD2/3:SMAD4 transcriptional activity (R-HSA-2173795)

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1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Reactome
Energy dependent regulation of mTOR by LKB1-AMPK
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Energy dependent regulation of mTOR by LKB1-AMPK
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (26)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
4
4
5
93.7
optic disc size measurement
2
2
2
82.7
optic cup area measurement
2
2
3
79.8
hair color
1
1
0
1.1
55.2
refractive error measurement
3
2
2
6.5
46.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cup-to-disc ratio measurement
5
93.7
optic disc size measurement
2
82.7
optic cup area measurement
3
79.8
hair color
0
1.1
55.2
refractive error measurement
2
6.5
46.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1A
VGNC:8292
452950
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1A
702987
Mouse
MGI:99878
19042
Rat
RGD:3373
24666
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1A
VGNC:44862
480344
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase, Mg2+/Mn2+ dependent 1A
Macaque
protein phosphatase, Mg2+/Mn2+ dependent 1A
Mouse
Rat
Dog
protein phosphatase, Mg2+/Mn2+ dependent 1A
Publication Statistics
PubMed Score 83.86
PubMed score by year
PubTator Score 68.07
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title