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Tchem
PPIP5K2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

Protein Summary
Description
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. This gene encodes a member of the histidine acid phosphatase family of proteins. Despite containing a histidine acid phosphatase domain, the encoded protein functions as an inositol pyrophosphate kinase, and is thought to lack pho ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321521
  • ENSP00000313070
  • ENSG00000145725
  • ENST00000358359
  • ENSP00000351126
  • ENST00000414217
  • ENSP00000416016

Symbol
  • HISPPD1
  • KIAA0433
  • VIP2
  • VIP2
  • IP7K2
  • CFAP160
  • DFNB100
  • HISPPD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
virus perturbation
0.85
cell type or tissue
0.65
cell line
0.59
microRNA
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.63   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.63   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (62)
CAPN2
Tchem
Novelty:  0.00431673
p_int:  0.999669555
p_ni:  0.000330438
p_wrong:  7e-9
Data Source:  BioPlex
CETN1
Tbio
Novelty:  0.01208917
p_int:  0.999026832
p_ni:  0.000970658
p_wrong:  0.000002511
Score:  0.193
Data Source:  BioPlex,STRINGDB
IL17RA
Tclin
Novelty:  0.00416706
p_int:  0.990090038
p_ni:  0.009906475
p_wrong:  0.000003487
Data Source:  BioPlex
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.987969388
p_ni:  0.011415131
p_wrong:  0.000615481
Data Source:  BioPlex
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.958726943
p_ni:  0.041045029
p_wrong:  0.000228028
Score:  0.163
Data Source:  BioPlex,STRINGDB
CELA3A
Tbio
Family:  Enzyme
Novelty:  0.04100319
p_int:  0.892119452
p_ni:  0.107754818
p_wrong:  0.000125729
Score:  0.219
Data Source:  BioPlex,STRINGDB
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
Score:  0.988
Data Source:  STRINGDB
IP6K3
Tbio
Family:  Kinase
Novelty:  0.13072912
Score:  0.988
Data Source:  STRINGDB
IP6K2
Tbio
Family:  Kinase
Novelty:  0.05004446
Score:  0.985
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.942
Data Source:  STRINGDB
Pathways (6)
Inositol phosphate metabolism (R-HSA-1483249)

Click on a row in the table to change the structure displayed.

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of pyrophosphates in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
2
1.2
83.5
mean corpuscular hemoglobin concentration
1
1
1
77.6
balding measurement
1
1
1
68.8
4
2
2
1.1
61.8
BMI-adjusted waist-hip ratio
2
2
2
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.2
83.5
mean corpuscular hemoglobin concentration
1
77.6
balding measurement
1
68.8
2
1.1
61.8
BMI-adjusted waist-hip ratio
2
61.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diphosphoinositol pentakisphosphate kinase 2
VGNC:4133
461976
Macaque
diphosphoinositol pentakisphosphate kinase 2
703458
Mouse
MGI:2142810
227399
Dog
diphosphoinositol pentakisphosphate kinase 2
VGNC:44860
488883
Horse
diphosphoinositol pentakisphosphate kinase 2
VGNC:21738
100064726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diphosphoinositol pentakisphosphate kinase 2
Macaque
diphosphoinositol pentakisphosphate kinase 2
Mouse
Dog
diphosphoinositol pentakisphosphate kinase 2
Horse
diphosphoinositol pentakisphosphate kinase 2
Publication Statistics
PubMed Score 32.63
PubMed score by year
PubTator Score 28.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title