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Tbio
PPIP5K1
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1

Protein Summary
Description
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. This gene encodes a dual functional inositol kinase. The encoded enzyme converts inositol hexakisphosphate to diphosphoinositol pentakisphosphate and diphosphoinositol penta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334933
  • ENSP00000334779
  • ENSG00000168781
  • ENST00000348806
  • ENSP00000308773
  • ENST00000360135
  • ENSP00000353253
  • ENST00000360301
  • ENSP00000353446
  • ENST00000396923
  • ENSP00000380129
  • ENST00000420765
  • ENSP00000400887

Symbol
  • HISPPD2A
  • IP6K
  • IPS1
  • KIAA0377
  • VIP1
  • IP6K
  • IPS1
  • VIP1
  • hsVIP1
  • HISPPD2A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
hub protein
0.88
virus perturbation
0.72
cell type or tissue
0.59
tissue
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 44   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.65   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 44   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (48)
IP6K1
Tbio
Family:  Kinase
Novelty:  0.03418032
Score:  0.99
Data Source:  STRINGDB
IP6K3
Tbio
Family:  Kinase
Novelty:  0.13072912
Score:  0.985
Data Source:  STRINGDB
IP6K2
Tbio
Family:  Kinase
Novelty:  0.05004446
Score:  0.984
Data Source:  STRINGDB
IPMK
Tbio
Family:  Kinase
Novelty:  0.01837813
Score:  0.975
Data Source:  STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
Score:  0.972
Data Source:  STRINGDB
ITPK1
Tbio
Family:  Kinase
Novelty:  0.02790263
Score:  0.954
Data Source:  STRINGDB
PPIP5K2
Tchem
Family:  Enzyme
Novelty:  0.0284462
Score:  0.903
Data Source:  STRINGDB
VAC14
Tbio
Novelty:  0.02677738
Score:  0.82
Data Source:  STRINGDB
CATSPER2
Tchem
Family:  IC
Novelty:  0.03701031
Score:  0.809
Data Source:  STRINGDB
STRC
Tbio
Novelty:  0.01587212
Score:  0.801
Data Source:  STRINGDB
Pathways (6)
Inositol phosphate metabolism (R-HSA-1483249)

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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Inositol phosphate metabolism
Reactome
Metabolism
Reactome
Synthesis of pyrophosphates in the cytosol
Name
Explore in Pharos
Explore in Source
Inositol phosphate metabolism
Metabolism
Synthesis of pyrophosphates in the cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (15)
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Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Disease Associations (null)
No disease associations found
GWAS Traits (40)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
25
2
30
98.1
high density lipoprotein cholesterol measurement
33
4
38
96.4
C-reactive protein measurement
4
2
4
89.9
serum gamma-glutamyl transferase measurement
3
3
3
89
very low density lipoprotein cholesterol measurement
45
3
45
87.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
30
98.1
high density lipoprotein cholesterol measurement
38
96.4
C-reactive protein measurement
4
89.9
serum gamma-glutamyl transferase measurement
3
89
very low density lipoprotein cholesterol measurement
45
87.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
diphosphoinositol pentakisphosphate kinase 1
VGNC:1896
100608132
Macaque
diphosphoinositol pentakisphosphate kinase 1
710588
Mouse
MGI:2443281
327655
Dog
diphosphoinositol pentakisphosphate kinase 1
VGNC:44859
478276
Horse
diphosphoinositol pentakisphosphate kinase 1
VGNC:21737
100070782
Species
Name
OMA
EggNOG
Inparanoid
Chimp
diphosphoinositol pentakisphosphate kinase 1
Macaque
diphosphoinositol pentakisphosphate kinase 1
Mouse
Dog
diphosphoinositol pentakisphosphate kinase 1
Horse
diphosphoinositol pentakisphosphate kinase 1
Publication Statistics
PubMed Score 95.65
PubMed score by year
PubTator Score 80.84
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title