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Tdark
PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

Protein Summary
Description
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). This gene is a member of the cyclophilin family of peptidylprolyl isomerases. The cyclophilins are a highly conserved family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253329
  • ENSP00000253329
  • ENSG00000131013

Symbol
  • HDCME13P
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
histone modification site profile
0.72
tissue sample
0.7
interacting protein
0.61
ligand (protein) perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 168   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.39   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 168   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (225)
DHX40
Tdark
Family:  Enzyme
Novelty:  0.27906444
p_int:  0.999999892
p_ni:  1.08e-7
Score:  0.231
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.999999038
p_ni:  9.55e-7
p_wrong:  7e-9
Data Source:  BioPlex
PES1
Tbio
Novelty:  0.07162845
p_int:  0.97846536
p_ni:  0.02153406
p_wrong:  5.79e-7
Score:  0.153
Data Source:  BioPlex,STRINGDB
RAB3IL1
Tbio
Novelty:  0.0167537
p_int:  0.975118265
p_ni:  0.024881732
p_wrong:  3e-9
Score:  0.209
Data Source:  BioPlex,STRINGDB
SNRNP27
Tbio
Novelty:  0.0175187
p_int:  0.951167542
p_ni:  0.048831953
p_wrong:  5.05e-7
Score:  0.912
Data Source:  BioPlex,STRINGDB
AMMECR1
Tbio
Novelty:  0.12679247
p_int:  0.93081937
p_ni:  0.069155897
p_wrong:  0.000024733
Score:  0.252
Data Source:  BioPlex,STRINGDB
ORC6
Tbio
Novelty:  0.02529139
p_int:  0.927516085
p_ni:  0.072454144
p_wrong:  0.000029771
Score:  0.226
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.867224231
p_ni:  0.132693239
p_wrong:  0.00008253
Score:  0.183
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.82099025
p_ni:  0.178994859
p_wrong:  0.000014892
Data Source:  BioPlex
NAGK
Tbio
Family:  Kinase
Novelty:  0.01603908
p_int:  0.819596299
p_ni:  0.180395992
p_wrong:  0.00000771
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
1
1
0
1.2
68.8
eosinophil count
2
2
2
58.2
brain stem volume measurement
1
1
0
6.7
49.5
eosinophil percentage of leukocytes
1
1
1
49.5
1
1
0
1.1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Dupuytren Contracture
0
1.2
68.8
eosinophil count
2
58.2
brain stem volume measurement
0
6.7
49.5
eosinophil percentage of leukocytes
1
49.5
0
1.1
31.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 4
VGNC:3665
472150
Macaque
peptidylprolyl isomerase like 4
696634
Mouse
MGI:1914668
67418
Rat
RGD:1311051
361449
Dog
peptidylprolyl isomerase like 4
VGNC:44857
484030
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase like 4
Macaque
peptidylprolyl isomerase like 4
Mouse
Rat
Dog
peptidylprolyl isomerase like 4
Publication Statistics
PubMed Score 2.39
PubMed score by year
PubTator Score 1.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title