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Tchem
PPIG
Peptidyl-prolyl cis-trans isomerase G

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260970
  • ENSP00000260970
  • ENSG00000138398
  • ENST00000448752
  • ENSP00000407083
  • ENST00000462903
  • ENSP00000435987

Symbol
  • CYP
  • SRCyp
  • SCAF10
  • CARS-Cyp
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
disease perturbation
0.79
hub protein
0.75
kinase
0.72
transcription factor binding site profile
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6332.73   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6332.73   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (266)
PNN
Tbio
Novelty:  0.01395394
p_int:  0.999695211
p_ni:  0.000303871
p_wrong:  9.18e-7
Score:  0.91
Data Source:  BioPlex,STRINGDB
EPB41L3
Tbio
Novelty:  0.00915217
p_int:  0.998802512
p_ni:  0.001197154
p_wrong:  3.34e-7
Data Source:  BioPlex
CLK3
Tchem
Family:  Kinase
Novelty:  0.03466191
p_int:  0.997282301
p_ni:  0.002698666
p_wrong:  0.000019032
Score:  0.766
Data Source:  BioPlex,STRINGDB
NKAPD1
Tdark
Novelty:  1.56979675
p_int:  0.996346327
p_ni:  0.003651884
p_wrong:  0.000001789
Score:  0.331
Data Source:  BioPlex,STRINGDB
JMJD6
Tchem
Family:  Enzyme
Novelty:  0.00305479
p_int:  0.996309244
p_ni:  0.003690756
Score:  0.298
Data Source:  BioPlex,STRINGDB
PIP4K2A
Tbio
Family:  Kinase
Novelty:  0.01130885
p_int:  0.996229896
p_ni:  0.003770104
Score:  0.173
Data Source:  BioPlex,STRINGDB
TRA2A
Tbio
Novelty:  0.04935993
p_int:  0.99599019
p_ni:  0.003984247
p_wrong:  0.000025563
Score:  0.668
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.995925157
p_ni:  0.004049398
p_wrong:  0.000025445
Score:  0.673
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.993929444
p_ni:  0.002273582
p_wrong:  0.003796974
Data Source:  BioPlex
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.982634171
p_ni:  0.017323797
p_wrong:  0.000042032
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
44.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase G
VGNC:14343
459718
Macaque
peptidylprolyl isomerase G
706262
Mouse
MGI:2445173
228005
Rat
RGD:620315
83624
Dog
peptidylprolyl isomerase G
VGNC:44853
607519
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase G
Macaque
peptidylprolyl isomerase G
Mouse
Rat
Dog
peptidylprolyl isomerase G
Publication Statistics
PubMed Score 6332.73
PubMed score by year
PubTator Score 418.58
PubTator score by year
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Related Publications
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PMID
Year
Title