You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPIE
Peptidyl-prolyl cis-trans isomerase E

Protein Summary
Description
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28076346). Combines RNA-binding and PPIase activities (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20460131). Binds mRNA and has a preference for single-stranded RNA molecules with poly-A and poly-U stretches, suggesting it binds to the poly(A)-region in the 3'-UTR of mRNA molecules (PubMed:8977107, PubMed:18258190, PubMed:20460131). Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins (PubMed:8977107, PubMed:18258190, PubMed:20677832, PubMed:20541251). Inhibits KMT2A activity; this requires proline isomerase activity (PubMed:20677832, PubMed:20541251, PubMed:20460131). The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (C ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324379
  • ENSP00000312769
  • ENSG00000084072
  • ENST00000356511
  • ENSP00000348904
  • ENST00000372830
  • ENSP00000361918

Symbol
  • CYP33
  • CYP33
  • CYP-33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
virus perturbation
0.83
histone modification site profile
0.76
disease perturbation
0.74
transcription factor perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 257   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (301)
ZNF830
Tdark
Novelty:  0.38957008
p_int:  0.999999969
p_ni:  1.2e-8
p_wrong:  1.9e-8
Score:  0.983
Data Source:  BioPlex,STRINGDB
ISY1
Tdark
Novelty:  1.68602768
p_int:  0.99999913
p_ni:  8.7e-7
Score:  0.862
Data Source:  BioPlex,STRINGDB
AQR
Tbio
Novelty:  0.00434312
p_int:  0.999998578
p_ni:  0.000001422
Score:  0.997
Data Source:  BioPlex,STRINGDB
SYF2
Tbio
Novelty:  0.06114903
p_int:  0.999988658
p_ni:  0.000011342
Score:  0.978
Data Source:  BioPlex,STRINGDB
XAB2
Tbio
Novelty:  0.04104647
p_int:  0.999982902
p_ni:  0.000017098
Score:  0.998
Data Source:  BioPlex,STRINGDB
TRMT61B
Tbio
Family:  Enzyme
Novelty:  0.32929047
p_int:  0.999715169
p_ni:  0.000284831
Score:  0.187
Data Source:  BioPlex,STRINGDB
USB1
Tbio
Family:  Enzyme
Novelty:  0.01677996
p_int:  0.999610528
p_ni:  0.000389472
Score:  0.815
Data Source:  BioPlex,STRINGDB
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999501659
p_ni:  0.000498341
Score:  0.686
Data Source:  BioPlex,STRINGDB
P0CG13
Tbio
Novelty:  0.15007488
p_int:  0.999186266
p_ni:  0.000802191
p_wrong:  0.000011543
Score:  0.187
Data Source:  BioPlex,STRINGDB
PRPF19
Tbio
Novelty:  0.01616737
p_int:  0.996029521
p_ni:  0.003970479
Score:  0.996
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Dual incision in TC-NER
Reactome
Formation of TC-NER Pre-Incision Complex
Reactome
Gap-filling DNA repair synthesis and ligation in TC-NER
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
DNA Repair
Dual incision in TC-NER
Formation of TC-NER Pre-Incision Complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (23)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
3
2
4
68.8
apolipoprotein A 1 measurement
1
1
1
29
red blood cell density measurement
1
1
1
12.4
appendicular lean mass
1
1
1
12.3
C-reactive protein measurement
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
68.8
apolipoprotein A 1 measurement
1
29
red blood cell density measurement
1
12.4
appendicular lean mass
1
12.3
C-reactive protein measurement
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase E
VGNC:6958
456784
Macaque
peptidylprolyl isomerase E
716340
Mouse
MGI:1917118
56031
Rat
RGD:1311411
298508
Dog
peptidylprolyl isomerase E
VGNC:44852
607232
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase E
Macaque
peptidylprolyl isomerase E
Mouse
Rat
Dog
peptidylprolyl isomerase E
Publication Statistics
PubMed Score 59.14
PubMed score by year
PubTator Score 24.07
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title