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Tchem
PPID
Peptidyl-prolyl cis-trans isomerase D

Protein Summary
Description
PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:11350175, PubMed:20676357). Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell vi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307720
  • ENSP00000303754
  • ENSG00000171497

Symbol
  • CYP40
  • CYPD
  • CYPD
  • CYP-40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
interacting protein
0.9
hub protein
0.85
protein domain
0.85
biological process
0.83


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.11   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 331   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.11   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 331   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (151)
PCBP4
Tbio
Novelty:  0.03763262
p_int:  0.999721961
p_ni:  0.000278036
p_wrong:  3e-9
Score:  0.329
Data Source:  BioPlex,STRINGDB
FGB
Tbio
Novelty:  0.00437751
p_int:  0.990179585
p_ni:  0.008946038
p_wrong:  0.000874377
Data Source:  BioPlex
UROD
Tbio
Family:  Enzyme
Novelty:  0.00337791
p_int:  0.980868418
p_ni:  0.019131581
Score:  0.359
Data Source:  BioPlex,STRINGDB
TGFA
Tbio
Novelty:  0.00216159
p_int:  0.943496817
p_ni:  0.046653982
p_wrong:  0.009849201
Data Source:  BioPlex
AEN
Tbio
Family:  Enzyme
Novelty:  0.04318322
p_int:  0.943373465
p_ni:  0.056587703
p_wrong:  0.000038832
Score:  0.221
Data Source:  BioPlex,STRINGDB
TMA16
Tdark
Novelty:  0.89810617
p_int:  0.943373465
p_ni:  0.056587703
p_wrong:  0.000038832
Score:  0.179
Data Source:  BioPlex,STRINGDB
FAM24B
Tdark
Novelty:  1.04675689
p_int:  0.896783749
p_ni:  0.086121197
p_wrong:  0.017095054
Data Source:  BioPlex
CCDC83
Tdark
Novelty:  0.2258549
p_int:  0.835529693
p_ni:  0.012030503
p_wrong:  0.152439805
Score:  0.187
Data Source:  BioPlex,STRINGDB
FGF9
Tbio
Novelty:  0.003428
p_int:  0.796564206
p_ni:  0.057192544
p_wrong:  0.14624325
Score:  0.202
Data Source:  BioPlex,STRINGDB
AMTN
Tbio
Novelty:  0.02514528
p_int:  0.796564206
p_ni:  0.057192544
p_wrong:  0.14624325
Score:  0.188
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (144)
ESR-mediated signaling (R-HSA-8939211)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ESR-mediated signaling
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Name
Explore in Pharos
Explore in Source
ESR-mediated signaling
Signal Transduction
Signaling by Nuclear Receptors
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
3
2
6
93.5
metabolite measurement
3
2
3
87.7
acylcarnitine measurement
1
1
2
70.2
serum metabolite measurement
1
1
2
54.4
intelligence
2
2
2
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
6
93.5
metabolite measurement
3
87.7
acylcarnitine measurement
2
70.2
serum metabolite measurement
2
54.4
intelligence
2
36.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase D
VGNC:666
737256
Macaque
peptidylprolyl isomerase D
701347
Mouse
MGI:1914988
67738
Rat
RGD:1303174
361967
Rat
RGD:1560149
501204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
peptidylprolyl isomerase D
Macaque
peptidylprolyl isomerase D
Mouse
Rat
Rat
Publication Statistics
PubMed Score 93.11
PubMed score by year
PubTator Score 155.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title