You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPHLN1
Periphilin-1

Protein Summary
Description
Component of the HUSH complex, a multiprotein complex that mediates epigenetic repression. The HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. In the HUSH complex, contributes to the maintenance of the complex at chromatin (PubMed:26022416). Acts as a transcriptional corepressor and regulates the cell cycle, probably via the HUSH complex (PubMed:15474462, PubMed:17963697). May be involved in epithelial differentiation by contributing to epidermal integrity and barrier formation (Probable). The protein encoded by this gene is one of the several proteins that become sequentially incorporated into the cornified cell envelope during the terminal differentiation of keratinocyte at the outer layers of epidermis. This protein interacts with periplakin, which is known as a precursor of the cornified cell envelope. ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358314
  • ENSP00000351066
  • ENSG00000134283
  • ENST00000395568
  • ENSP00000378935
  • ENST00000395580
  • ENSP00000378947
  • ENST00000432191
  • ENSP00000393965
  • ENST00000449194
  • ENSP00000390681
  • ENST00000552761
  • ENSP00000449331
  • ENST00000610488
  • ENSP00000479913
  • ENST00000613154
  • ENSP00000478872
  • ENST00000619544
  • ENSP00000477681

Symbol
  • CR
  • HSPC206
  • HSPC232
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
ligand (protein) perturbation
0.83
transcription factor binding site profile
0.82
kinase perturbation
0.81
virus perturbation
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 136   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.32   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 136   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (43)
ERH
Tbio
Novelty:  0.00711649
p_int:  0.999988141
p_ni:  0.000011859
Data Source:  BioPlex
MFAP4
Tbio
Novelty:  0.02023782
p_int:  0.999984752
p_ni:  0.000015248
Data Source:  BioPlex
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999981625
p_ni:  0.000018375
Data Source:  BioPlex
APOBEC3D
Tbio
Novelty:  0.01102619
p_int:  0.999925426
p_ni:  0.000074574
Data Source:  BioPlex
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.999811657
p_ni:  0.000188343
Score:  0.439
Data Source:  BioPlex,STRINGDB
HNRNPLL
Tbio
Novelty:  0.0498467
p_int:  0.999662255
p_ni:  0.000337744
Data Source:  BioPlex
ZFC3H1
Tbio
Novelty:  0.17313739
p_int:  0.999603243
p_ni:  0.000392604
p_wrong:  0.000004154
Data Source:  BioPlex
ZNF597
Tbio
Family:  TF
Novelty:  0.04420398
p_int:  0.999472162
p_ni:  0.000527726
p_wrong:  1.13e-7
Score:  0.226
Data Source:  BioPlex,STRINGDB
KLHL40
Tbio
Novelty:  0.0432945
p_int:  0.999345522
p_ni:  0.000654432
p_wrong:  4.6e-8
Data Source:  BioPlex
DAXX
Tbio
Novelty:  0.00348585
p_int:  0.998918159
p_ni:  0.000982927
p_wrong:  0.000098914
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
2
2
2
82.2
appendicular lean mass
1
1
1
45
corneal resistance factor
1
1
1
44.7
comparative body size at age 10, self-reported
1
1
1
27.9
diastolic blood pressure
1
1
1
12.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood urea nitrogen measurement
2
82.2
appendicular lean mass
1
45
corneal resistance factor
1
44.7
comparative body size at age 10, self-reported
1
27.9
diastolic blood pressure
1
12.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
periphilin 1
VGNC:5540
451837
Macaque
periphilin 1
701728
Mouse
MGI:1917029
223828
Rat
RGD:1306207
366975
Dog
periphilin 1
477639
Species
Name
OMA
EggNOG
Inparanoid
Chimp
periphilin 1
Macaque
periphilin 1
Mouse
Rat
Dog
periphilin 1
Publication Statistics
PubMed Score 5.32
PubMed score by year
PubTator Score 2.24
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title