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Tbio
PPFIA3
Liprin-alpha-3

Protein Summary
Description
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. Liprin family protein has been shown to localize phosphatase LAR to cell focal adhesions and may be involved in the molecular organization of presynaptic active zones. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000334186
  • ENSP00000335614
  • ENSG00000177380
  • ENST00000602351
  • ENSP00000473622

Symbol
  • KIAA0654
  • LPNA3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
transcription factor binding site profile
0.7
histone modification site profile
0.69
gene perturbation
0.65
transcription factor
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.53   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (122)
GPS2
Tbio
Novelty:  0.00986158
p_int:  0.999999853
p_ni:  1.47e-7
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.999999628
p_ni:  6e-8
p_wrong:  3.12e-7
Data Source:  BioPlex
RAB3IL1
Tbio
Novelty:  0.0167537
p_int:  0.999999466
p_ni:  5.2e-8
p_wrong:  4.82e-7
Score:  0.267
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999997639
p_ni:  0.00000236
Score:  0.483
Data Source:  BioPlex,STRINGDB
CCDC113
Tdark
Novelty:  1.10748096
p_int:  0.999996533
p_ni:  0.000003466
Data Source:  BioPlex
MED4
Tbio
Family:  Enzyme
Novelty:  0.01200585
p_int:  0.999989216
p_ni:  0.000010784
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999591231
p_ni:  0.000391727
p_wrong:  0.000017042
Data Source:  BioPlex
PTPRF
Tchem
Family:  Enzyme
Novelty:  0.01017327
Score:  0.981
Data Source:  Reactome,STRINGDB
UNC13B
Tbio
Novelty:  0.00429808
Score:  0.977
Data Source:  Reactome,STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.976
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Acetylcholine Neurotransmitter Release Cycle (R-HSA-264642)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acetylcholine Neurotransmitter Release Cycle
Reactome
Dopamine Neurotransmitter Release Cycle
Reactome
Glutamate Neurotransmitter Release Cycle
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Name
Explore in Pharos
Explore in Source
Acetylcholine Neurotransmitter Release Cycle
Dopamine Neurotransmitter Release Cycle
Glutamate Neurotransmitter Release Cycle
Neuronal System
Neurotransmitter release cycle
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ParkinsonsUK-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
67.7
body mass index
1
1
1
31.4
heel bone mineral density
1
1
1
31.4
electrocardiography
1
1
3
30.1
ferritin measurement
1
1
1
20.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
67.7
body mass index
1
31.4
heel bone mineral density
1
31.4
electrocardiography
3
30.1
ferritin measurement
1
20.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PTPRF interacting protein alpha 3
719106
Mouse
MGI:1924037
76787
Rat
RGD:620054
140591
Dog
PTPRF interacting protein alpha 3
VGNC:44845
484387
Horse
PTPRF interacting protein alpha 3
VGNC:21724
100054955
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PTPRF interacting protein alpha 3
Mouse
Rat
Dog
PTPRF interacting protein alpha 3
Horse
PTPRF interacting protein alpha 3
Publication Statistics
PubMed Score 25.53
PubMed score by year
PubTator Score 5.21
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title