Protein Summary
Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mamma ...more
- ENST00000333447
- ENSP00000327416
- ENSG00000139220
- ENST00000407050
- ENSP00000385093
- ENST00000443686
- ENSP00000388373
- ENST00000541017
- ENSP00000445532
- ENST00000541570
- ENSP00000438337
- ENST00000548586
- ENSP00000449338
- ENST00000549325
- ENSP00000450298
- ENST00000549396
- ENSP00000450337
- ENST00000552948
- ENSP00000447868
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.73 | ||
cell type or tissue | 0.7 | ||
histone modification site profile | 0.68 | ||
tissue sample | 0.61 | ||
microRNA | 0.54 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.85 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 70 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.85 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 70 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (101)
Nearest Tclin Targets
Pathways (10)
Reactome (10)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acetylcholine Neurotransmitter Release Cycle | ||||
Reactome | Dopamine Neurotransmitter Release Cycle | ||||
Reactome | Glutamate Neurotransmitter Release Cycle | ||||
Reactome | Neuronal System | ||||
Reactome | Neurotransmitter release cycle | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acetylcholine Neurotransmitter Release Cycle | ||||
Dopamine Neurotransmitter Release Cycle | ||||
Glutamate Neurotransmitter Release Cycle | ||||
Neuronal System | ||||
Neurotransmitter release cycle | ||||
Viral Interactions (0)
Gene Ontology Terms (9)
Functions (1)
Components (6)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 5 | 3 | 5 | 64.3 | |||||
alcohol use disorder measurement | 1 | 1 | 1 | 46.1 | |||||
creatinine measurement | 1 | 1 | 1 | 33.1 | |||||
mathematical ability | 1 | 1 | 1 | 17.8 | |||||
glomerular filtration rate | 1 | 1 | 1 | 4.5 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
alcohol consumption measurement | 5 | 64.3 | |||||
alcohol use disorder measurement | 1 | 46.1 | |||||
creatinine measurement | 1 | 33.1 | |||||
mathematical ability | 1 | 17.8 | |||||
glomerular filtration rate | 1 | 4.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | PTPRF interacting protein alpha 2 | VGNC:8493 | 452101 | |||||
Macaque | PTPRF interacting protein alpha 2 | 698065 | ||||||
Mouse | MGI:2443834 | 327814 | ||||||
Rat | RGD:1305021 | 362876 | ||||||
Dog | PTPRF interacting protein alpha 2 | VGNC:44844 | 475415 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | PTPRF interacting protein alpha 2 | |||||
Macaque | PTPRF interacting protein alpha 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | PTPRF interacting protein alpha 2 | |||||
Publication Statistics
PubMed Score 6.85
PubMed score by year
PubTator Score 3.43
PubTator score by year
Related Publications
Text Mined References (17)
GeneRif Annotations (6)
Items per page:
0 of 0
PMID | Year | Title |
|---|