Tbio PPFIA2 Liprin-alpha-2

Protein Summary

Description

Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein has been shown to bind the calcium/calmodulin-dependent serine protein kinase (MAGUK family) protein (also known as CASK) and proposed to regulate higher-order brain functions in mammals. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• O75334
• B3KVT5
• B3KXA0
• B7Z2A6
• B7Z3U9
• B7Z663
• B7ZKZ5
• E7ERB8
• E7ETG6
• F8VP68
• Q2M3G8

Gene Name

• PPFIA2

Ensembl ID

• ENST00000333447
• ENSP00000327416
• ENSG00000139220
• ENST00000407050
• ENSP00000385093
• ENST00000443686
• ENSP00000388373
• ENST00000541017
• ENSP00000445532
• ENST00000541570
• ENSP00000438337
• ENST00000548586
• ENSP00000449338
• ENST00000549325
• ENSP00000450298
• ENST00000549396
• ENSP00000450337
• ENST00000552948
• ENSP00000447868

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.73
cell type or tissue	0.7
histone modification site profile	0.68
tissue sample	0.61
microRNA	0.54

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.06   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.06   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0