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Tbio
PPEF2
Serine/threonine-protein phosphatase with EF-hands 2

Protein Summary
Description
May play a role in phototransduction. May dephosphorylate photoactivated rhodopsin. May function as a calcium sensing regulator of ionic currents, energy production or synaptic transmission. This gene encodes a member of the serine/threonine protein phosphatase with EF-hand motif family. The protein contains a protein phosphatase catalytic domain, and at least two EF-hand calcium-binding motifs in its C terminus. Although its substrate(s) is unknown, the encoded protein, which is expressed specifically in photoreceptors and the pineal, has been suggested to play a role in the visual system. This gene shares high sequence similarity with the Drosophila retinal degeneration C (rdgC) gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286719
  • ENSP00000286719
  • ENSG00000156194
  • ENST00000621010
  • ENSP00000483398

Symbol
  • PPP7CB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
trait
0.86
cell type or tissue
0.84
molecular function
0.81
biological process
0.66


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.03   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 61   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.03   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 61   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (37)
EFCAB2
Tdark
Novelty:  0.26420728
Score:  0.677
Data Source:  STRINGDB
RHO
Tbio
Family:  GPCR
Novelty:  0.00012925
Score:  0.66
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.638
Data Source:  STRINGDB
LRIT2
Tdark
Novelty:  2.59170397
Score:  0.589
Data Source:  STRINGDB
MAP3K5
Tchem
Family:  Kinase
Novelty:  0.00144614
Score:  0.55
Data Source:  STRINGDB
NFATC1
Tchem
Family:  TF
Novelty:  0.00130337
Score:  0.548
Data Source:  STRINGDB
CALM2
Tclin
Novelty:  0.01876254
Score:  0.546
Data Source:  STRINGDB
CALM3
Tclin
Novelty:  0.00461552
Score:  0.546
Data Source:  STRINGDB
LRIT1
Tdark
Novelty:  0.77720636
Score:  0.543
Data Source:  STRINGDB
PPP1R8
Tbio
Family:  Enzyme
Novelty:  0.00138054
Score:  0.526
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
1
1
0
1.5
57.8
monokine induced by gamma interferon measurement
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-X-C motif chemokine 10 measurement
0
1.5
57.8
monokine induced by gamma interferon measurement
1
45.7
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase with EF-hand domain 2
VGNC:8177
471202
Macaque
protein phosphatase with EF-hand domain 2
701103
Mouse
MGI:1342304
19023
Rat
RGD:1307093
305246
Horse
protein phosphatase with EF-hand domain 2
VGNC:21722
100050916
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein phosphatase with EF-hand domain 2
Macaque
protein phosphatase with EF-hand domain 2
Mouse
Rat
Horse
protein phosphatase with EF-hand domain 2
Publication Statistics
PubMed Score 5.03
PubMed score by year
PubTator Score 1.62
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title