Tbio PPCS Phosphopantothenate--cysteine ligase

Protein Summary

Description

Catalyzes the first step in the biosynthesis of coenzyme A from vitamin B5, where cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. Biosynthesis of coenzyme A (CoA) from pantothenic acid (vitamin B5) is an essential universal pathway in prokaryotes and eukaryotes. PPCS (EC 6.3.2.5), one of the last enzymes in this pathway, converts phosphopantothenate to phosphopantothenoylcysteine (Daugherty et al., 2002 [PubMed 11923312]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• Q9HAB8
• Q3KQT2
• Q5VVM0

Gene Name

• PPCS

Ensembl ID

• ENST00000372561
• ENSP00000361642
• ENSG00000127125
• ENST00000372562
• ENSP00000361643

Symbol

• COAB
• CMD2C

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.92
virus perturbation	0.79
transcription factor binding site profile	0.73
kinase perturbation	0.71
cellular component	0.64

Protein Classes

PANTHER Classes

Protein / Ligase / Phosphopantothenate--cysteine Ligase

DTO Classes

Protein / Enzyme / Ligase / Phosphopantothenate--cysteine Ligase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.76   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 77   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.76   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0