Tbio PPARGC1A Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

Protein Summary

Description

Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as ARNTL/BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9UBK2
• B7Z406
• G8DM16
• I3RTT5
• I3RTT6
• I3RTT7
• I3RTT8
• I3RTT9
• Q3LIG1
• Q4W5M7
• Q9UN32
• PGC-1-alpha

Gene Name

• PPARGC1A

Ensembl ID

• ENST00000264867
• ENSP00000264867
• ENSG00000109819
• ENST00000506055
• ENSP00000423075
• ENST00000513205
• ENSP00000421632
• ENST00000613098
• ENSP00000481498

Symbol

• LEM6
• PGC1
• PGC1A
• PPARGC1
• LEM6
• PGC1
• PGC1A
• PGC-1v
• PPARGC1
• PGC-1alpha
• PGC-1(alpha)

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
molecular function	0.96
chemical	0.92
gene perturbation	0.91
transcription factor perturbation	0.91

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Cofactor / Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-alpha

DTO Classes

Protein / Transcription Factor / Transcription Cofactor / Peroxisome Proliferator-activated Receptor Gamma Coactivator 1-alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3769.16   (req: < 5)

Gene RIFs: 646   (req: <= 3)

Antibodies: 292   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3769.16   (req: >= 5)

Gene RIFs: 646   (req: > 3)

Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 98

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0