PPARG
Peroxisome proliferator-activated receptor gamma
Protein Summary
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. This gene encodes a member of the peroxisome proliferator-acti ...more
- ENST00000287820
- ENSP00000287820
- ENSG00000132170
- ENST00000309576
- ENSP00000312472
- ENST00000396999
- ENSP00000380195
- ENST00000397010
- ENSP00000380205
- ENST00000397012
- ENSP00000380207
- ENST00000397015
- ENSP00000380210
- ENST00000643197
- ENSP00000495840
- ENST00000643888
- ENSP00000494934
- ENST00000644622
- ENSP00000494873
- NR1C3
- GLM1
- CIMT1
- NR1C3
- PPARG1
- PPARG2
- PPARgamma
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
chemical | 1 | ||
molecular function | 1 | ||
drug | 0.99 | ||
ligand (chemical) | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12245.77 (req: < 5)
Gene RIFs: 1774 (req: <= 3)
Antibodies: 986 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12245.77 (req: >= 5)
Gene RIFs: 1774 (req: > 3)
Antibodies: 986 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 113
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1357
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13