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Tclin
PPARG
Peroxisome proliferator-activated receptor gamma

Protein Summary
Description
Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut homeostasis by suppressing NF-kappa-B-mediated proinflammatory responses. Plays a role in the regulation of cardiovascular circadian rhythms by regulating the transcription of ARNTL/BMAL1 in the blood vessels (By similarity). (Microbial infection) Upon treatment with M.tuberculosis or its lipoprotein LpqH, phosphorylation of MAPK p38 and IL-6 production are modulated, probably via this protein. This gene encodes a member of the peroxisome proliferator-acti ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287820
  • ENSP00000287820
  • ENSG00000132170
  • ENST00000309576
  • ENSP00000312472
  • ENST00000396999
  • ENSP00000380195
  • ENST00000397010
  • ENSP00000380205
  • ENST00000397012
  • ENSP00000380207
  • ENST00000397015
  • ENSP00000380210
  • ENST00000643197
  • ENSP00000495840
  • ENST00000643888
  • ENSP00000494934
  • ENST00000644622
  • ENSP00000494873

Symbol
  • NR1C3
  • GLM1
  • CIMT1
  • NR1C3
  • PPARG1
  • PPARG2
  • PPARgamma
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
1
drug
0.99
ligand (chemical)
0.98


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12245.77   (req: < 5)
Gene RIFs: 1518   (req: <= 3)
Antibodies: 986   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12245.77   (req: >= 5)
Gene RIFs: 1518   (req: > 3)
Antibodies: 986   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 113
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1357
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13