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Tclin
PPARA
Peroxisome proliferator-activated receptor alpha

Protein Summary
Description
Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2. Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid meta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262735
  • ENSP00000262735
  • ENSG00000186951
  • ENST00000402126
  • ENSP00000385246
  • ENST00000407236
  • ENSP00000385523

Symbol
  • NR1C1
  • PPAR
  • PPAR
  • NR1C1
  • hPPAR
  • PPARalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
chemical
1
molecular function
1
virus perturbation
0.97
disease
0.94


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6945.74   (req: < 5)
Gene RIFs: 406   (req: <= 3)
Antibodies: 706   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6945.74   (req: >= 5)
Gene RIFs: 406   (req: > 3)
Antibodies: 706   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 752
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12