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Tbio
POU5F1B
Putative POU domain, class 5, transcription factor 1B

Protein Summary
Description
Shows weak transcriptional activator activity. This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]
Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.55   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.55   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (40)
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.81
Data Source:  STRINGDB
POU5F1
Tbio
Family:  TF
Novelty:  0.00033974
Score:  0.806
Data Source:  STRINGDB
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.732
Data Source:  STRINGDB
CDX2
Tbio
Family:  TF
Novelty:  0.00081636
Score:  0.617
Data Source:  STRINGDB
FAM84B
Tbio
Novelty:  0.10702561
Score:  0.586
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.577
Data Source:  STRINGDB
TRIM10
Tbio
Novelty:  0.27685659
Score:  0.559
Data Source:  STRINGDB
RNF39
Tbio
Novelty:  0.0340178
Score:  0.549
Data Source:  STRINGDB
TBXT
Tbio
Family:  TF
Novelty:  0.00660122
Score:  0.544
Data Source:  STRINGDB
PPP1R11
Tbio
Family:  Enzyme
Novelty:  0.08166535
Score:  0.539
Data Source:  STRINGDB
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
17
13
2
1.4
99.7
1
9
0
1.2
99
17
5
0
1.2
98.1
7
4
0
1.1
94.1
1
2
0
1.2
93.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.4
99.7
0
1.2
99
0
1.2
98.1
0
1.1
94.1
0
1.2
93.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 22.55
PubMed score by year
PubTator Score 11.84
PubTator score by year
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Related Publications
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Year
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