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Tbio
POU5F1
POU domain, class 5, transcription factor 1

Protein Summary
Description
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259915
  • ENSP00000259915
  • ENSG00000204531
  • ENST00000376243
  • ENSP00000365419
  • ENSG00000206454
  • ENST00000383524
  • ENSP00000373016
  • ENST00000412166
  • ENSP00000387646
  • ENSG00000229094
  • ENST00000419095
  • ENSP00000413622
  • ENSG00000235068
  • ENST00000429314
  • ENSP00000387619
  • ENSG00000237582
  • ENST00000429603
  • ENSP00000392877
  • ENSG00000233911
  • ENST00000433063
  • ENSP00000405041
  • ENST00000433348
  • ENSP00000412665
  • ENSG00000230336
  • ENST00000434616
  • ENSP00000388842
  • ENST00000437747
  • ENSP00000391681
  • ENST00000451077
  • ENSP00000391507
  • ENST00000454714
  • ENSP00000400047

Symbol
  • OCT3
  • OCT4
  • OTF3
  • OCT3
  • OCT4
  • OTF3
  • OTF4
  • OTF-3
  • Oct-3
  • Oct-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus
0.98
viral protein
0.93
protein domain
0.92
disease
0.79
PubMedID
0.78


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3258.01   (req: < 5)
Gene RIFs: 483   (req: <= 3)
Antibodies: 1330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3258.01   (req: >= 5)
Gene RIFs: 483   (req: > 3)
Antibodies: 1330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (445)
SOX2
Tbio
Family:  TF
Novelty:  0.00037089
Score:  0.999
Data Source:  Reactome,STRINGDB
NANOG
Tbio
Family:  TF
Novelty:  0.00054893
Score:  0.999
Data Source:  Reactome,STRINGDB
LIN28A
Tbio
Family:  TF
Novelty:  0.00199524
Score:  0.996
Data Source:  STRINGDB
KLF4
Tbio
Family:  TF
Novelty:  0.00076828
Score:  0.994
Data Source:  STRINGDB
SALL4
Tbio
Family:  TF
Novelty:  0.00354374
Score:  0.994
Data Source:  STRINGDB
TDGF1
Tbio
Novelty:  0.00527099
Score:  0.987
Data Source:  STRINGDB
FOXD3
Tbio
Family:  TF
Novelty:  0.00550321
Score:  0.984
Data Source:  STRINGDB
FGF2
Tchem
Novelty:  0.00007856
Score:  0.979
Data Source:  STRINGDB
DPPA4
Tbio
Novelty:  0.05764302
Score:  0.975
Data Source:  STRINGDB
PRDM14
Tbio
Family:  TF; Epigenetic
Novelty:  0.01776592
Score:  0.973
Data Source:  STRINGDB
Pathways (14)
Developmental Biology (R-HSA-1266738)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Reactome
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Reactome
Transcriptional regulation of pluripotent stem cells
Name
Explore in Pharos
Explore in Source
Developmental Biology
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation
Transcriptional regulation of pluripotent stem cells
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (37)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (714)
Items per page:
1 – 5 of 714
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
9
9
13
99.4
leukocyte count
9
9
13
99.4
leukocyte count
9
9
13
99.4
leukocyte count
9
9
13
99.4
leukocyte count
9
9
13
99.4
Items per page:
1 – 5 of 714
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
leukocyte count
13
99.4
leukocyte count
13
99.4
leukocyte count
13
99.4
leukocyte count
13
99.4
leukocyte count
13
99.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
POU class 5 homeobox 1
744263
Macaque
POU class 5 homeobox 1
714760
Species
Name
OMA
EggNOG
Inparanoid
Chimp
POU class 5 homeobox 1
Macaque
POU class 5 homeobox 1
Publication Statistics
PubMed Score 3258.01
PubMed score by year
PubTator Score 2141.86
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title