You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POU3F4
POU domain, class 3, transcription factor 4

Protein Summary
Description
Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373200
  • ENSP00000362296
  • ENSG00000196767

Symbol
  • BRN4
  • OTF9
  • BRN4
  • DFN3
  • OTF9
  • BRN-4
  • DFNX2
  • OCT-9
  • OTF-9
  • BRAIN-4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
biological process
0.59
gene perturbation
0.51
transcription factor
0.51
cell line
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.9   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.9   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0