Tbio POU3F4 POU domain, class 3, transcription factor 4

Protein Summary

Description

Probable transcription factor which exert its primary action widely during early neural development and in a very limited set of neurons in the mature brain. This gene encodes a member of the POU-III class of neural transcription factors. This family member plays a role in inner ear development. The protein is thought to be involved in the mediation of epigenetic signals which induce striatal neuron-precursor differentiation. Mutations in this gene are associated with X chromosome-linked nonsyndromic mixed deafness. [provided by RefSeq, Dec 2012]

Uniprot Accession IDs

• P49335
• B2RC71
• Q5H9G9
• Q99410

Gene Name

• POU3F4

Ensembl ID

• ENST00000373200
• ENSP00000362296
• ENSG00000196767

Symbol

• BRN4
• OTF9
• BRN4
• DFN3
• OTF9
• BRN-4
• DFNX2
• OCT-9
• OTF-9
• BRAIN-4

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
biological process	0.59
gene perturbation	0.51
transcription factor	0.51
cell line	0.5

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.9   (req: < 5)

Gene RIFs: 31   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 135.9   (req: >= 5)

Gene RIFs: 31   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0